Results 51 to 60 of about 2,420,887 (329)

Informed Consent in Biomedical Research

Computational and Structural Biotechnology Journal, 2019
Informed consent is the result of tumultuous events in both the clinical and research arenas over the last 100 years. Throughout this time, the notion of informed consent has shifted tremendously, both due to advances in medicine, as well as the type of ...
Fida K. Dankar, Marton Gergely, Samar K. Dankar   +2 more
doaj   +1 more source

Biomedical Research Involving Prisoners: Ethical Values and Legal Regulation [PDF]

, 2007
Until the early 1970\u27s, approximately 90% of all pharmaceutical research was conducted on prisoners, who were also subjected to biochemical research, including studies involving dioxin and chemical warfare agents.
Gostin, Lawrence O.
core   +1 more source

Public views on the donation and use of human biological samples in biomedical research: a mixed methods study [PDF]

, 2013
Objective A mixed methods study exploring the UK general public's willingness to donate human biosamples (HBSs) for biomedical research.<p></p> Setting Cross-sectional focus groups followed by an online survey.<p></p> ...
Clotworthy, M., Corfield, J., Hilton, S., Lewis, C., MaGee, C., Robertson, M.J., Stubbins, L.J.   +6 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Organs-on-Chips: Revolutionizing Biomedical Research

Biophysica
Organs-on-Chips (OoC) technology has begun to be considered a pragmatic tool for drug evaluation, offering researchers an opportunity to move beyond the less physiologically relevant animal models.
Ankit Monga, Khush Jain, Harvinder Popli, Prashik Telgote, Ginpreet Kaur, Fariah Rizwani, Ritu Chauhan, Damandeep Kaur, Abhishek Chauhan, Hardeep Singh Tuli   +9 more
doaj   +1 more source

BMC Biomedical Engineering: a home for all biomedical engineering research

BMC Biomedical Engineering, 2019
This editorial accompanies the launch of BMC Biomedical Engineering, a new open access, peer-reviewed journal within the BMC series, which seeks to publish articles on all aspects of biomedical engineering. As one of the first engineering journals within
Alexandros Houssein, Alan Kawarai Lefor, Antonio Veloso, Zhi Yang, Jong Chul Ye, Dimitrios I. Zeugolis, Sang Yup Lee   +6 more
doaj   +1 more source

Time to Reflect on Global Health Agenda in Kenya: A Tribute to our Academic and Biomedical Research Mentors [PDF]

, 2021
Bartholomew N. Ondigo, Ann M. Moormann, Chandy C. John   +2 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Disease activity and cognition in rheumatoid arthritis : an open label pilot study [PDF]

, 2012
Acknowledgements This work was supported in part by NIHR Newcastle Biomedical Research Centre. Funding for this study was provided by Abbott Laboratories.
Birchall, Daniel, Blamire, Andrew M, He, Jiabao, Isaacs, John D, Newton, Julia L, Pearce, Ruth, Raftery, Graham   +6 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source