Results 81 to 90 of about 2,451,565 (299)

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

ВЗАИМОСВЯЗЬ ГИПЕРАКТИВАЦИИ СИГНАЛЬНОГО ПУТИ mTOR, ПРОЦЕССОВ СТАРЕНИЯ И ПАТОГЕНЕЗА COVID-19 (ОБЗОР ЛИТЕРАТУРЫ)

open access: yesРоссийские биомедицинские исследования, 2023
Одной из наиболее актуальных проблем современного здравоохранения является старение населения планеты и распространение ассоциированных со старением заболеваний.
И.А. Баранов   +2 more
doaj  

Librarian teachers on the move : are video tutorials an effective alternative tool for library information literacy instruction?: a case study [PDF]

open access: yes, 2012
The Ghent Biomedical Library research group has performed research over the last year on teaching information literacy in the Biomedical curriculum. The impact of a differentiated teaching methodology was studied in a framework of blended learning, with ...
De Sutter, Daisy
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Undergraduate Research Fellows to Present Scientific Research at Annual SURF Conference on July 28 [PDF]

open access: yes, 2017
Culminating a 10-week fellowship, 19 RWU students will present diverse research on the impact of climate change on the environment and biomedical ...
Public Affairs, Roger Williams University
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Aspectos Éticos de la Investigación Clínica en seres humanos Clinic research in human beings: Ethical aspect

open access: yesHumanidades Médicas, 2003
La ética de la experimentación con seres humanos no es sólo una de las áreas fundamentales de la bioética, sino también una de las problemáticas que le dieron origen.
Carlos M Albornoz López del Castillo   +3 more
doaj  

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