Results 101 to 110 of about 5,682,413 (331)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
bioRxiv, 2018 The association between GRE scores and academic success in graduate programs is currently of national interest. GRE scores are often assumed to be predictive of student success in graduate school.
L. Sealy +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The Biomedical Workforce in the US: An Example of Positive Feedbacks [PDF]
This paper makes the case that the biomedical workforce in the United States is characterized by positive feedbacks. The paper begins by setting out background information on (1) the way in which research is structured in the biomedical sciences; (2) the
Paula E. Stephan
core
edge2vec: Representation learning using edge semantics for biomedical knowledge discovery
, 2019 Representation learning provides new and powerful graph analytical approaches and tools for the highly valued data science challenge of mining knowledge graphs.
Ding, Ying +10 more
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
MORAL REASONING OF STUDENTS OF DIFFERENT PROFESSIONAL CHOICES
Facta Universitatis. Series, Teaching, Learning and Teacher Education, 2019 The goal of this research was to investigate the differences in moral reasoning among students of social, biomedical and technical sciences. The sample included 300 students of both genders (154 male and 146 female students).
Mirjana Đokić, Snažana Stojiljković
doaj +1 more source
CBE - Life Sciences Education, 2017 This study explores whether academic career “coaching” is a potential source of social support for PhD students in the biomedical sciences. For many of the underrepresented racial and ethnic minority PhD students, coaching provided additional social ...
S. Williams +2 more
semanticscholar +1 more source