Results 91 to 100 of about 500,852 (334)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Quality-on-Demand Compression of EEG Signals for Telemedicine Applications Using Neural Network Predictors

open access: yesInternational Journal of Telemedicine and Applications, 2011
A telemedicine system using communication and information technology to deliver medical signals such as ECG, EEG for long distance medical services has become reality.
N. Sriraam
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Mobile System for the Prevention, Diagnosis, and Personalized Treatment of Neck Pain Under a Patient’s Everyday Life Circumstances

open access: yesCurrent Directions in Biomedical Engineering, 2019
This work presents a new system concept for the prevention, diagnosis and interactive treatment of neck pain. It comprises two measurement units worn at the head and the torso, a smartphone/tablet and a medical assistance software.
Tadayon Puian   +3 more
doaj   +1 more source

The ClassA Framework: HRV Based Assessment of SNS and PNS Dynamics Without LF-HF Controversies

open access: yesFrontiers in Physiology, 2019
The powers of the low frequency (LF) and high frequency (HF) components of heart rate variability (HRV) have become the de facto standard metrics in the assessment of the stress response, and the related activities of the sympathetic nervous system (SNS)
Tricia Adjei   +4 more
doaj   +1 more source

A Hidden Markov Factor Analysis Framework for Seizure Detection in Epilepsy Patients [PDF]

open access: yes, 2019
Approximately 1% of the world population suffers from epilepsy. Continuous long-term electroencephalographic (EEG) monitoring is the gold-standard for recording epileptic seizures and assisting in the diagnosis and treatment of patients with epilepsy ...
Madadi, Mahboubeh
core   +2 more sources

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