Results 51 to 60 of about 504,300 (287)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Variable-rate data sampling for low-power microsystems using modified Adams methods [PDF]

, 2003
A method for variable-rate data sampling is proposed for the purpose of low-power data acquisition in a small footprint microsystem. The procedure enables energy saving by utilizing dynamic power management techniques and is based on the Adams-Bashforth ...
Cumming, D.R.S., Dickman, P., Irvine, G.B., Wang, L.   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Программно-аппаратный комплекс по цифровой обработке сигналов [PDF]

, 2016
В процессе исследования проводилась разработка лабораторного комплекса по проектированию цифровых фильтров различного типа с использованием как программных, так и аппаратных приложений, разработка программного обеспечения для обработки биомедицинских ...
Киселева, Виктория Андреевна
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Reliable Biomarker discovery from Metagenomic data via RegLRSD algorithm

BMC Bioinformatics, 2017
Background Biomarker detection presents itself as a major means of translating biological data into clinical applications. Due to the recent advances in high throughput sequencing technologies, an increased number of metagenomics studies have suggested ...
Mustafa Alshawaqfeh, Ahmad Bashaireh, Erchin Serpedin, Jan Suchodolski   +3 more
doaj   +1 more source

Noninvasive assessment of inspiratory muscle neuromechanical coupling during inspiratory threshold loading [PDF]

, 2019
Diaphragm neuromechanical coupling (NMC), which reflects the efficiency of conversion of neural activation to transdiaphragmatic pressure (Pdi), is increasingly recognized to be a useful clinical index of diaphragm function and respiratory mechanics in ...
Estrada Petrocelli, Luis Carlos, Jané Campos, Raimon, Jolley, J, Lozano García, Manuel, Moxham, John, Rafferty, Gerrard F., Torres Cebrián, Abel   +6 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Challenges in Reproducibility, Replicability, and Comparability of Computational Models and Tools for Neuronal and Glial Networks, Cells, and Subcellular Structures

Frontiers in Neuroinformatics, 2018
The possibility to replicate and reproduce published research results is one of the biggest challenges in all areas of science. In computational neuroscience, there are thousands of models available.
Tiina Manninen, Tiina Manninen, Jugoslava Aćimović, Jugoslava Aćimović, Riikka Havela, Riikka Havela, Heidi Teppola, Heidi Teppola, Marja-Leena Linne, Marja-Leena Linne   +9 more
doaj   +1 more source

Unobtrusive detection of Parkinson’s disease from multi-modal and in-the-wild sensor data using deep learning techniques

Scientific Reports, 2020
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, affecting more than 1% of the population above 60 years old with both motor and non-motor symptoms of escalating severity as it progresses. Since it cannot be cured, treatment
Alexandros Papadopoulos, Dimitrios Iakovakis, Lisa Klingelhoefer, Sevasti Bostantjopoulou, K. Ray Chaudhuri, Konstantinos Kyritsis, Stelios Hadjidimitriou, Vasileios Charisis, Leontios J. Hadjileontiadis, Anastasios Delopoulos   +9 more
doaj   +1 more source