SPG4 and Dementia: Expanding the Clinical Spectrum
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
WS06: Post Penicillin Antibiotics: From Acceptance to Resistance? (12-May-1998)
Selection of photos taken at the Witness Seminar “Post penicillin antibiotics” held by the History of Twentieth Century Medicine Group, 12-May-1998. Participants: Dr Geoffrey Asherson, Professor Graham Ayliffe, Dr Derek Bangham, Dr Basil Bard, Dr Ralph ...
core
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
WS18: Foot and Mouth Disease: The 1967 outbreak and its aftermath (11-Dec-2001)
Selection of photos taken at the Witness Seminar “Foot and Mouth Disease: The 1967 outbreak and its aftermath” held by the History of Twentieth Century Medicine Group, 11-Dec-2001.
core
[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich +19 more
wiley +1 more source
WS02c: Drugs in Psychiatric Practice (11-Mar-1997)
Selection of photos taken at the Witness Seminar “Drugs in Psychiatric Practice” held by the History of Twentieth Century Medicine Group, 11-Mar-1997. Participants: Dr Derek Bangham, Professor George Beaumont, Sir Christopher Booth, Dr Alan Broadhurst ...
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Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan +14 more
wiley +1 more source
WS03: Early Heart Transplant Surgery in the UK (10-Jun-1997)
Selection of photos taken at the Witness Seminar “The First Heart Transplant in the UK in the UK” held by the History of Twentieth Century Medicine Group, 10-Jun-1997.
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Blood-invigorating Chinese herbal medicines plus conventional therapy for endometriosis: a network meta-analysis of 107 randomized controlled trials. [PDF]
Liu W, Xu L, Jia J, Xu M, Tian Y.
europepmc +1 more source
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng +4 more
wiley +1 more source

