Results 41 to 50 of about 68,738 (254)

Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming

Cell Regeneration, 2020
Retinoic acid (RA) and 2-phospho-L-ascorbic acid trisodium salt (AscPNa) promote the reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells.
Mengdan Zhang, Qian Li, Tingting Yang, Fei Meng, Xiaowei Lai, Lining Liang, Changpeng Li, Hao Sun, Jiaqi Sun, Hui Zheng   +9 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Nematode Extract and Acaciasides Use as Preventive Biomedicines Against Plant Diseases: Improved Earth-Environmental-Health-Research Science-TechnologyCommunication and May be Controlled 21st-Century Pandemic Diseases!

Earth & Environmental Science Research & Reviews, 2021
Traditional chemical control using chemical pesticides available for the last few decades is in a declining status internationally. Thus, there remains a need for developing effective biomedicines which would be cheap, non-phytotoxic, and non-pollutant.
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade

Journal of Virology
Mast cells (MCs) are strategically located at the interface between host and environment. The non-allergic functions of MCs in immunosurveillance against pathogens have been recently underscored.
Shuang Zhang, Chu-Lan Xu, Jingjing Wang, Xiaoli Xiong, Jian-Hua Wang   +4 more
doaj   +1 more source

Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism

Nature Communications, 2023
Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific proteins on individual endosomes,
Harrison M. York, Kunaal Joshi, Charles S. Wright, Laura Z. Kreplin, Samuel J. Rodgers, Ullhas K. Moorthi, Hetvi Gandhi, Abhishek Patil, Christina A. Mitchell, Srividya Iyer-Biswas, Senthil Arumugam   +10 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The burden of chronic pain and the role of neurorehabilitation: consensus matters where evidence is lacking

Journal of Pain Research, 2017
Stefano Tamburin,1 Stefano Paolucci,2 Nicola Smania,1,3 Giorgio Sandrini4,51Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, 2Santa Lucia Foundation, IRCCS, Rome, 3Neuromotor and Cognitive Rehabilitation ...
Tamburin S, Paolucci S, Smania N, Sandrini G   +3 more
doaj  

‘Community-Case-Study-Reports’ of ‘Spices-Community-Biomedicines-Physiology’ Act as ‘Archives of Preventive-Booster-Community-Vaccines’ Against ‘Any-‘A-Z’-Diseases’ By Immunizing Public-Health-Socio-Economy-Environment-Wildlife-Biodiversity-Conservation-Science-Technology-Communication-Applications-Ecology

Archives of Community Medicine and Public Health, 2022
Introduction: Both the 1st-and 4th-pandemic outbreaks by SARS-CoV-2/3 causing COVID-19, starts in Wuhan, China, badly affecting human civilization with sever-post-COVID-diseases weakening the ability of COVID-19-vaccines to prevent-SARS-CoV-2/3-infection-or-reinfection with side effects.
openaire   +1 more source