Results 41 to 50 of about 185,073 (295)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Generation of two MEN1 knockout lines from a human embryonic stem cell line

Stem Cell Research, 2017
The MEN1 gene is cytogenetically located at 11q13.1 and encodes the nuclear protein menin, which is involved in cell proliferation, apoptosis, differentiation, and metabolism. Here, we generated two MEN1 knockout human embryonic stem cell lines, WAe001-A-
Yanli Liu, Aynisahan Ruzi, Dongsheng Guo, Feima Wu, Haikun Liu, Han Wu, Yuhang Wu, Fang Yuan, Yuanqi Zhuang, Fan Yang, Keyu Lai, Liangxue Lai, Yin-xiong Li   +12 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Utilization of big data to improve management of the emergency departments. Results of a systematic review [PDF]

, 2017
Background. The emphasis on using big data is growing exponentially in several sectors including biomedicine, life sciences and scientific research, mainly due to advances in information technologies and data analysis techniques.
DE VITO, Corrado, DI PAOLO, Carolina, Iorio, Silvia, Mele, Annamaria, Migliara, Giuseppe, Prencipe, GRAZIA PIA   +5 more
core  

Analytic philosophy for biomedical research: the imperative of applying yesterday's timeless messages to today's impasses [PDF]

, 2020
The mantra that "the best way to predict the future is to invent it" (attributed to the computer scientist Alan Kay) exemplifies some of the expectations from the technical and innovative sides of biomedical research at present.
A Armiento, A Gare, A Hilfinger, A Karmon, A Lin, A Ross-Gillespie, A Sekikawa, A Zuniga, AA Thompson, AC Oates, AD Asatryan, AI Tauber, AL Byrd, AM Hosios, AM Jaeger, AP Monaco, B Berger, B Rehermann, BP Abbott, BW O’Malley, C Glymour, C Kadelka, C Willyard, CA Tulk, CN Bagot, Collaboration Open Science, CT Walsh, D Reker, D Wallach, DC Clary, DJ Depew, DJ Nicholson, DP Norris, DY Gouvêa, E Bizzi, E Del Soldato, E Piskounova, E Toprak, Editors, EJ Louis, F Davidoff, F Leigh, F Rohwer, FE Abbot, GJ Romanes, GJ Toomer, GM Bodner, GM Brodeur, H Braak, H Ledford, H Varmus, HB Frieboes, HJ Anders, HL Van Epps, HM Lopez, HS Chung, I Brigandt, IL Markov, IM Lonie, J Couzin-Frankel, J Dong, J Elf, J Greene, J Gunawardena, J Gunawardena, J Lister, J Manchak, J Odenbaugh, J Raspopovic, J Su, JA Barnett, JC Cardwell, JE Allen, JF Fisher, JH Woodger, JI Seeman, JJ McNeil, JM Barry, JM Tanner, JN Weiss, JP Capp, JP Robinson, JRA, JS Steffan, JT Leek, K Arney, K Lewis, K Neupane, K Servick, K Shrinivas, KT Smith, L Tadrist, LA DiMeglio, LA Hug, M Baym, M Buchanan, M Delling, M Friedman, M Greaves, M Kramer, M Levin, M Nei, M Niepel, M Pigliucci, M Schaapveld, M Thamer, MA McCormick, MB Everaert, MC Marchetti, MD Hauser, ME Feder, N Chomsky, N Chomsky, N Yang, N Yucel, NQ Balaban, OR Jones, P Bauer, P Griffiths, P Lieshout, P McNamara, P Robustelli, Plato, PN Singer, Q Justman, Q Zhong, R Chatterjee, R Chen, R Gregory, R Kolter, R Losick, R MacCoun, R Scholl, RC Berwick, RC Lewontin, RJ Britten, RL Wasserstein, RM Nesse, RV Christie, RZ Moger-Reischer, S Bartley, S Cukierman, S Gordon, S Kannan, S Kryazhimskiy, S Ling, S Smit, S Uphoff, S Wong, SA Hoption Cann, SH Orzack, SJ Biller, SJ Diede, SM Connell, SM Fleming, SM Mozaffari, TA Carey, TE Kottke, TG Nakashige, V Lazar, W Shou, W Szybalski, WD Casebeer, X Wei, XS Xie, Y Hatwalne, YE Nikiforov   +166 more
core   +1 more source

No differences in FBN1 genotype between men with and without abdominal aortic aneurysm

BMC Cardiovascular Disorders, 2023
Background Abdominal aortic aneurysm (AAA) is an aortic enlargement in which the transverse diameter reaches at least 30 mm. Certain risk factors, such as age, male gender, and smoking, are well known; however, less is known about the genetic factors ...
Ida Åström Malm, Rachel De Basso, Peter Blomstrand   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A ‘healthy baby’: The double imperative of preimplantation genetic diagnosis [PDF]

, 2010
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 The Authors.This article reports from a study exploring the social processes, meanings and institutions that frame and produce ...
Casper, M.J., Chambliss, D., Clare Williams, Foucault, M., Grint, K., Kathryn Ehrich, Lofland, J., Quintavalle, J., Thompson, C., Williams, C.   +9 more
core   +1 more source

Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts

Stem Cell Research & Therapy, 2019
Background The limited proliferative ability of hepatocytes is a major limitation to meet their demand for cell-based therapy, bio-artificial liver device, and drug tests. One strategy is to amplify cells at the hepatoblast (HB) stage. However, expansion
Tingcai Pan, Yan Chen, Yuanqi Zhuang, Fan Yang, Yingying Xu, Jiawang Tao, Kai You, Ning Wang, Yuhang Wu, Xianhua Lin, Feima Wu, Yanli Liu, Yingrui Li, Guodong Wang, Yin-xiong Li   +14 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source