Results 61 to 70 of about 42,986 (314)

High temperature induces reproductive dysfunction in male zebrafish via DNA methylation-mediated tssk6 downregulation

Ecotoxicology and Environmental Safety
High temperature (HT) poses a significant threat to aquatic organisms, yet the molecular mechanisms underlying HT-induced reproductive impairment in fish remain unclear. In this study, we demonstrated that both short-term (< 21 days) and long-term (> 120
Xuan Ma, Rongjian Liu, Zhongchang Ren, Yongmei Qi, Dongqiong Wei, Jiamin Shi, Samra., Cong Yuan, Dejun Huang   +8 more
doaj   +1 more source

Pesticide Contamination in the Hair of Children From Colonia San Juan, a Rural Community in Paraguay

Drug Testing and Analysis, EarlyView.
Hair analysis in children from a rural community in Paraguay reveals exposure to organophosphates, pyrethroids, neonicotinoids, fungicides, herbicides, and endocrine disruptors, highlighting the urgent need for stricter environmental protections and preventive health measures. ABSTRACT Chronic exposure to pesticides can cause carcinogenic, reproductive,
Stela Benitez Leite, Alba Iglesias‐Gonzalez, Mirta Noemí Mesquita, María Luisa Macchi, Robin Mesnage, Brice M. R. Appenzeller   +5 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Phloretin Suppresses Preadipocyte Differentiation by Targeting PPARγ/Transferrin to Activate Ferroptosis Signaling Pathway

Food Frontiers, EarlyView.
Phloretin alleviates HFD‐induced obesity and suppresses adipogenesis by activating the ferroptosis pathway, potentially via targeting PPARγ and transferrin. ABSTRACT Phloretin, a plant‐derived dihydrochalcone bioactive compound, potentially modulates preadipocyte differentiation, although this remains controversial and requires further clarification ...
Jie Li, Qihui Zhu, Yang Li, Haiyu Zhao, Yi Bi, Chuanying Pan, Min Wang, Lin Han, Xianyong Lan   +8 more
wiley   +1 more source

Is Micronucleus Assay a Suitable Biomarker for Evaluating the Cancer Risk in Professionals Exposed to Antineoplastic Drugs? A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT The widespread use of antineoplastic drugs in cancer treatment has led to significant concerns regarding the potential health risks posed to healthcare professionals involved in the preparation, administration, and handling of these chemical compounds, including genotoxicity.
Thiago Guedes Pinto, Lorrany da Silva Avanci, Gabriel Carvalhal de Aguiar, Daniel Vitor de Souza, Patricia Ramos Cury, Ana Claudia Muniz Renno, Daniel Araki Ribeiro   +6 more
wiley   +1 more source

A harmonized occupational biomonitoring approach

Environment International
Biomonitoring has been widely used in assessing exposures in both occupational and public health complementing chemical risk assessments because it measures the concentrations of chemical substances in human body fluids (e.g., urine and blood ...
Nancy B. Hopf, Christophe Rousselle, Devika Poddalgoda, Farida Lamkarkach, Jos Bessems, Kaspar Schmid, Kate Jones, Koki Takaki, Ludwine Casteleyn, Maryam Zare Jeddi, Michael Bader, Michael Koller, Patience Browne, Rex FitzGerald, Susana Viegas, Thomas Göen, Tiina Santonen, Virpi Väänänen, Radu - Corneliu Duca, Robert Pasanen-Kase   +19 more
doaj   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Ecosystem biomonitoring with eDNA: metabarcoding across the tree of life in a tropical marine environment

Scientific Reports, 2017
Effective marine management requires comprehensive data on the status of marine biodiversity. However, efficient methods that can document biodiversity in our oceans are currently lacking.
M. Stat, M. Huggett, Rachele Bernasconi, J. DiBattista, T. Berry, S. Newman, E. Harvey, M. Bunce   +7 more
semanticscholar   +1 more source

Environmental DNA‐based RPA‐CRISPR/Cas12a assay for on‐site detection of chironomid larvae in aquatic environments

Pest Management Science, EarlyView.
An environmental DNA (eDNA)‐based recombinase polymerase amplification (RPA)‐CRISPR/Cas12a assay enables rapid, specific, and on‐site detection of chironomids, supporting early warning, and ecological monitoring in freshwater environments. Abstract BACKGROUND Freshwater chironomid midges pose a significant threat to drinking water quality and ...
Kyuhyeong Kim, Bhavya Kachiprath, In‐Cheol Yeo, Kyu‐Young Shim, Ihn‐Sil Kwak, Chang‐Bum Jeong   +5 more
wiley   +1 more source

Habitat fragmentation increases the risk of local extinction of small reptiles: A case study on Phrynocephalus przewalskii

Ecotoxicology and Environmental Safety
Habitat fragmentation represents a multifaceted global conservation threat, exerting both direct and indirect effects on individual animals and communities.
Cui Yang, Yue Qi, Jiayuan Guo, Liangfei Peng, Neng Xiong, Wenya Zhang, Wei Zhao   +6 more
doaj   +1 more source