Advanced Science, EarlyView.A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang +9 more
wiley +1 more source
Pembrolizumab in metastatic hormone-sensitive prostate cancer: lessons from the negative KEYNOTE-991 trial. [PDF]
Transl Androl UrolMcKenzie J, Azad AA.
europepmc +1 more source
Global Nitrogen Deposition Promotes Carbon Sink Formation in Terrestrial Ecosystems
Advanced Science, EarlyView.Nitrogen deposition alleviates ecosystem N limitation and enhances carbon sinks. Using 829 observations, we show 36% of deposited N is retained globally (39.15 Tg N yr−1), with distinct NHx and NOy contributions. This retention drives a terrestrial C sink of 0.88 Pg C yr−1 (25.48%), highlighting the importance of pool‐specific C:N stoichiometry ...
Lei Li +6 more
wiley +1 more source
Differential associations of childhood abuse and neglect with neural responses to social reward and punishment in adults with anxiety or depression. [PDF]
Transl PsychiatrySpaulding IG, Stein MB, Taylor CT.
europepmc +1 more source
Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
Impact of environmental factors on the bionomics of <i>Anopheles</i> mosquito vectors of zoonotic malaria: A narrative review. [PDF]
One HealthMasse RS +9 more
europepmc +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Parasitoidism of Dermaptera by Braconidae (Hymenoptera) confirmed. [PDF]
ZookeysHsu YC, Rédei D.
europepmc +1 more source
Advanced Science, EarlyView.In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei +17 more
wiley +1 more source
Bionomics of Anopheles gambiae complex (Diptera: Culicidae) and malaria transmission pattern in a pre-elimination area in South-Western Senegal. [PDF]
Malar JDiop M +19 more
europepmc +1 more source