Results 101 to 110 of about 101,810 (380)

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release [PDF]

, 2014
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to im-prove their
Allemandi, Daniel Alberto, Castro, Silvina Gabriela, González Vidal, Noelia Luján, Palma, Santiago Daniel, Sanchez Bruni, Sergio Fabian   +4 more
core   +1 more source

Overcoming Biopharmaceutical Interferents for Quantitation of Host Cell DNA Using an Automated, High-Throughput Methodology [PDF]

, 2022
Mackenzie L. Lauro, Amy Bowman, Joseph P. Smith, Susannah N. Gaye, Jillian Acevedo‐Skrip, Pete A. DePhillips, John W. Loughney   +6 more
openalex   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

From Business model to Business model portfolio in the european biopharmaceutical industry [PDF]

At the crossroad of firm's core competencies and of the anticipations of consumers' needs, the business model approach complements corporate and business strategy approaches.
Tristan Rouselle, Valérie Sabatier, Vincent Mangematin   +2 more
core  

Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective

Frontiers in Pharmacology, 2018
Numerous bacteria utilize molecular communication systems referred to as quorum sensing (QS) to synchronize the expression of certain genes regulating, among other aspects, the expression of virulence factors and the synthesis of biofilm. To achieve this
B. Rémy, Sonia Mion, Laure Plener, M. Elias, E. Chabrière, D. Daudé   +5 more
semanticscholar   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Amphiphilic block polymer-based self-assembly of high payload nanoparticles for efficient combinatorial chemo-photodynamic therapy

Drug Delivery, 2020
Combinatorial chemo-photodynamic therapy is regared as effective cancer therapy strategy, which could be realized via multiple nano-drug delivery system.
Qisan Ma, Yanna Zhao, Qingran Guan, Yuping Zhao, Huaizhen Zhang, Zhuang Ding, Qingpeng Wang, Yushu Wu, Min Liu, Jun Han   +9 more
doaj   +1 more source

Technological Discontinuities and the Comparative Strategic Value of New Capabilites: Evidence from the Comparison of Small- and Large-Molecule Targeted Anti-Cancer Drug Discovery [PDF]

Traditional creative destruction theories distinguish disruptions as competence-destroying or competence-enhancing to incumbents’ capabilities, with the former case resulting in incumbents’ loss of competitive advantage in in-house R&D performance (even ...
M. Lourdes Sosa
core  

Evaluation of liposomes coated with a pH responsive polymer [PDF]

, 2010
Liposomes have been coated with the pH responsive polymer, Eudragit S100, and the formulation's potential for lower gastrointestinal (GI) targeting following oral administration assessed.
Barea, M.J., Bridson, R.H., Gaber, M.H., Jenkins, M.J.   +3 more
core   +1 more source

Biopharmaceuticals: Priority Sector Report

, 2019
The Biopharmaceuticals emerging industry is the result of an evolution of the traditional pharmaceutical industry that emerged in the late 1800s, mainly based on chemical production. The industry has incorporated the more recent emergence of biotechnology developed on living cells and molecules, stemming from key innovations in the 1970s and 1980s ...
openaire   +2 more sources