Results 101 to 110 of about 98,340 (384)

The Current Status, Trend, and Development Strategies of Chinese Biopharmaceutical Industry With a Challenging Perspective

SAGE Open, 2020
Biopharmaceutical technology is one of the most promising biotechnologies in the world. With the development of modern biotechnology, biopharmaceuticals are thriving and developing rapidly as a global high-tech biotechnology industry, bringing the ...
Kerong Zhang, Wuyi Liu
doaj   +1 more source

Chlorin e6-associated photodynamic therapy enhances abscopal antitumor effects via inhibition of PD-1/PD-L1 immune checkpoint

Scientific Reports, 2023
We hypothesized that photodynamic therapy (PDT) with Chlorin e6 (Ce6) enhances antitumor abscopal effects via inhibition of the programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint.
Pallavi Gurung, Junmo Lim, Rajeev Shrestha, Yong-Wan Kim   +3 more
doaj   +1 more source

Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective

Frontiers in Pharmacology, 2018
Numerous bacteria utilize molecular communication systems referred to as quorum sensing (QS) to synchronize the expression of certain genes regulating, among other aspects, the expression of virulence factors and the synthesis of biofilm. To achieve this
B. Rémy, Sonia Mion, Laure Plener, M. Elias, E. Chabrière, D. Daudé   +5 more
semanticscholar   +1 more source

Evaluation of liposomes coated with a pH responsive polymer [PDF]

, 2010
Liposomes have been coated with the pH responsive polymer, Eudragit S100, and the formulation's potential for lower gastrointestinal (GI) targeting following oral administration assessed.
Barea, M.J., Bridson, R.H., Gaber, M.H., Jenkins, M.J.   +3 more
core   +1 more source

A Hypoxia‐Responsive Single‐Atom Sonozyme for Targeted Sonocatalytic Therapy in Alleviating Atherosclerotic Plaque

Advanced Science, EarlyView.
A tetranitrogen‐coordinated single‐atom manganese catalyst (SMC) is fabricated with outstanding sonosensitization efficiency and multi‐enzyme‐like catalytic properties. To enable better targeting of M1 macrophages, hyaluronic acid (HA) is applied to modify the surface of SMC, yielding SMC‐HA nanozymes.
Qiaofei Chen, Guotao Yuan, Zhiwen Liu, Zhengyu Cao, Li He, Ruonan Li, Tongsheng Huang, Minglong Zheng, Kexin Wen, Canxia Huang, Shuang Zhu, Pingyu Zhang, Jingfeng Wang, Yuling Zhang, Yue Pan   +14 more
wiley   +1 more source

Defining the root cause of reduced H1N1 live attenuated influenza vaccine effectiveness: low viral fitness leads to inter-strain competition

npj Vaccines, 2021
In the 2013–14 and 2015–16 influenza seasons, reduced vaccine effectiveness (VE) was observed for the H1N1 component of the FluMist quadrivalent live attenuated influenza vaccine (QLAIV) in the USA, leading to loss of Advisory Committee on Immunization ...
Oliver Dibben, Jonathan Crowe, Shaun Cooper, Laura Hill, Katarzyna E. Schewe, Helen Bright   +5 more
doaj   +1 more source

A modified weighted log-rank test for confirmatory trials with a high proportion of treatment switching [PDF]

, 2020
In confirmatory cancer clinical trials, overall survival (OS) is normally a primary endpoint in the intention-to-treat (ITT) analysis under regulatory standards. After the tumor progresses, it is common that patients allocated to the control group switch
Bore, Alexander, Burman, Carl-Fredrik, Jiménez, José L., Niewczas, Julia   +3 more
core   +2 more sources

Foresight on biopharmaceuticals: Designing foresight methods for Spanish biopharmaceuticals

Technological Forecasting and Social Change, 2007
Abstract This paper has as its starting point the analysis of the systemic failures in the Spanish Biopharmaceutical Innovation System grounded in the study carried out by the same authors for the OECD between 2002 and 2004. Based on the evidence that one of the main failures is the lack of sufficient linkages between the different actors involved in
GUTIERREZ DE MESA Emma, MUÑOZ Emilio
openaire   +3 more sources

Supramolecular PEGylation of biopharmaceuticals [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Pharmaceutical practice has transitioned away from small-molecule drugs to the use of biomolecules (peptides, proteins, and antibodies). Where formulation of small molecules focused primarily on solubility, biopharmaceuticals introduced an array of complications due to their more complex secondary and tertiary structures ...
Robert Langer, Lavanya S. Thapa, Lavanya S. Thapa, Matthew J. Webber, Matthew J. Webber, Daniel G. Anderson, Abel B. Cortinas, Siddharth Jhunjhunwala, Eric A. Appel, Brittany Vinciguerra, Lyle Isaacs   +10 more
openaire   +3 more sources

Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation

Advanced Science, EarlyView.
A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo, Huang Yang, Xiaoming Jiang, Zheng Wang, Xuxiao He, Ying Meng, Shan Li, Min Li, Daqian Xu, Zhengwei Mao, Zhimin Lu   +10 more
wiley   +1 more source