Results 111 to 120 of about 98,340 (384)

Reduced Pressure Ionization Enhances Native Mass Spectrometry of Proteins and Protein Complexes

Angewandte Chemie, EarlyView.
Reduced pressure for electrospray ionization of native proteins narrows peak widths and increases signal. This straightforward add‐on to existing native MS platforms improves performance in challenging buffers and enables detection of protein interactions at concentrations as low as 50 nM, without significantly disrupting structure as confirmed by ...
Jake P. Violi, Chong Zhang, William A. Donald   +2 more
wiley   +2 more sources

Influence of Substrate Concentrations on the Performance of Fed-Batch and Perfusion Bioreactors: Insights from Mathematical Modelling

ChemEngineering
Fed-batch and perfusion bioreactors are commonly used in biopharmaceutical production. This study applies mathematical models to investigate the influence of substrate concentration in the media added (Sm), operating substrate concentration in the ...
John J. Fitzpatrick, Fionn O'Leary, Ali Hill, James Daly, Fergal Lalor, Edmond P. Byrne   +5 more
doaj   +1 more source

Considerations for applying bioethics norms to a biopharmaceutical industry setting

BMC Medical Ethics, 2021
Background The biopharmaceutical industry operates at the intersection of life sciences, clinical research, clinical care, public health, and business, which presents distinct operational and ethical challenges.
Luann E. Van Campen, Tatjana Poplazarova, Donald G. Therasse, Michael Turik, The Biopharmaceutical Bioethics Working Group   +4 more
doaj   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Xiao Yang, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li   +11 more
wiley   +1 more source

Current technologies to endotoxin detection and removal for biopharmaceutical purification

Biotechnology and Bioengineering, 2019
Endotoxins are the major contributors to the pyrogenic response caused by contaminated pharmaceutical products, formulation ingredients, and medical devices.
Mason Schneier, Sidharth Razdan, Allison M. Miller, Maria E Briceno, Sutapa Barua   +4 more
semanticscholar   +1 more source

ASH2L‐K312‐Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, ASH2L‐K312‐lac is identified as a critical driver that promotes the malignant progression of hepatocellular carcinoma (HCC). Furthermore, through a comprehensive series of cell biological and molecular biological experiments, integrated with diverse animal models and systematic application of high‐throughput sequencing technologies, it ...
Hexu Han, Shuai Wang, Lixing Ma, Haimeng Yin, Xinxiang Cheng, YiFan Wang, Suqin Xia, Yi Zhang, Yue Zhang, Rong Zhu, Cuixia Liu, Dakun Zhao, Xiangqian Gu, He Zhu, Yin Yuan   +14 more
wiley   +1 more source

Bio‐Inspired SA‐FA Bionic Dual Receptor Electronic Skin for Intelligent Gesture and Material Cognition Systems Enhanced by Static‐Dynamic Mutual Interaction

Advanced Science, EarlyView.
In this work, bionic dual receptor (BDR) e‐skin based on the iontronic and triboelectric effects is proposed, inspired by the slow‐adapting and fast‐adapting receptors. Motivated by intelligent software algorithms and high‐speed hardware circuits, the proposed intelligent autonomous material cognition system integrated with the EDB e‐skin can ...
Hao Li, Hongsen Niu, Hao Kan, Eun‐Seong Kim, Nam‐Young Kim, Yang Li   +5 more
wiley   +1 more source

Hierarchically Porous Multiphase Si‐Based Ceramics with Synergistic Electromagnetic Wave Absorption Mechanisms

Advanced Science, EarlyView.
A novel multiphase Si‐based ceramic material with hierarchical porosity is devised via one‐step etching activation of carbon‐rich polycarbosilane ceramics. Integrating free carbon, SiC crystals, amorphous SiOC, and engineered porosity, the material surprisingly achieves exceptional electromagnetic absorption performance, offering new insights into the ...
Jiaojiao Jiang, Xiaomei Deng, Sihan Li, Xiaojun Zeng, Chunxiao Wu, Chao Yang   +5 more
wiley   +1 more source

Linker‐regulated Imine‐based Covalent Organic Frameworks Enable Dual‐Mode Fluorescence Emission as Stable Internal Reference Signal

Aggregate, EarlyView.
Imine‐based covalent organic frameworks achieve dual fluorescence through synergistic aggregation‐induced emission and excited‐state intramolecular proton transfer effects, suppressing aggregation‐caused quenching and enhancing emission. This intrinsic signal functions as an internal reference, while integration with Sc3⁺ sensitization constructs ...
Xuequan Jing, Peihai Ju, Huimin Xie, Meina Guo, Huifeng Zeng, Hongdong Yu, Kang Hu, Tinggang Li, Yinhua Wan, Hongbin Cao   +9 more
wiley   +1 more source

A systematic screening of neural network‐based hybrid models of adsorption in chromatography processes

AIChE Journal, EarlyView.
Abstract In this study, various adsorption models using neural networks were developed and integrated into a mechanistic chromatography transport model, resulting in hybrid models. A systematic screening of 10 different hybrid model structures was performed to find the optimal balance between mechanistic and data‐driven components in modeling ...
Jesper Frandsen, Vinicius V. Santana, Peter Jul‐Rasmussen, Idelfonso B.R. Nogueira, Jakob K. Huusom, Krist V. Gernaey, Jens Abildskov   +6 more
wiley   +1 more source