Results 141 to 150 of about 98,340 (384)
VertigO, 2009 During the years 1980’s, the Canadian government decided to stimulate the development of biotechnologies in order to become a leader in this sector.
Marie-Hélène Bacon
doaj
Technological Knowledge Base, R&D Organization Structure and Alliance Formation: Evidence from the Biopharmaceutical Industry [PDF]
We explore how an incumbent firm's internal knowledge and organization structure influences its strategic alliance formation. We propose that the firm's knowledge breadth and the centrality of its R&D organization structure positively influence its ...
Charles Baden-Fuller +2 more
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Biopharmaceuticals: Priority Sector Report
, 2019 The Biopharmaceuticals emerging industry is the result of an evolution of the traditional pharmaceutical industry that emerged in the late 1800s, mainly based on chemical production. The industry has incorporated the more recent emergence of biotechnology developed on living cells and molecules, stemming from key innovations in the 1970s and 1980s ...
openaire +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims Glucagon‐like peptide‐1 (GLP‐1) and glucagon dual receptor agonists are in clinical development for a range of metabolic conditions, including type 2 diabetes and obesity. The cardiovascular actions at these receptors are well studied, but less is known about their combination.
James Goodman +13 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee +5 more
wiley +1 more source
Enhanced Vatiquinone Bioavailability With Fatty Meals and Optimal Dosing Schedule
Biopharmaceutics &Drug Disposition, EarlyView.This investigation discusses two clinical studies. One investigated the effect of fatty meals (≥ 25% fat) on vatiquinone PK exposures, and the other one characterized vatiquinone PK profiles when administered on a TID dosing regimen corresponding to mealtimes. The data support the recommendation of administering vatiquinone with fatty meals (≥ 25% fat)
Lucy Lee +6 more
wiley +1 more source
npj VaccinesSelecting a booster vaccine strategy that generates cellular immune breadth is crucial for effectively recalling cellular reservoirs upon infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants.
Durgesh Kumar +16 more
doaj +1 more source
Challenges of developing decision-support LCA tools in the biopharmaceutical industry [PDF]
, 2013 The biopharmaceutical industry has been slow in carrying out LCA analyses. However, as the industry matures, the level of scrutiny placed on this industry by international governments will increase and hence, there is an urgent need for the industry to ...
Lettieri, P +2 more
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Comprehensive Mapping of Functional Enhancers in Chinese Hamster Ovary Cells
Biotechnology and Bioengineering, EarlyView.In this study, the authors identified regions with enhancer activity in the CHO cell genome using genome‐wide and targeted STARR‐seq. The analysis revealed thousands of newly identified enhancer sequences, where some of the most active sequences could drive transgene expression at levels similar to or higher than strong viral enhancers.
María Santos +9 more
wiley +1 more source
Lectin based glycoprotein analysis [PDF]
, 2008 Many of the biopharmaceutical therapeutics entering the market and currently in clinical trails are recombinant glycoprotein molecules, the glycan moieties of which have a significant impact on efficacy and immunogenicity.
Clarke, Paul A. +4 more
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