Results 241 to 250 of about 70,680 (286)

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, EarlyView.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Machine Learning-Enabled Image Comparability Assessment for Flow Imaging Microscopy Across Platforms. [PDF]

Pharmaceuticals (Basel)
Zhou Z, Guo S, Tian Y, Li H, Qi Z, Chen X, Li J, Li D, He P, Wu H.   +9 more
europepmc   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

MediaAssist: database to support the design and optimization of cell culture medium. [PDF]

Nucleic Acids Res
Thakar K, Madhugiri I, Gadgil C, Gadgil M.   +3 more
europepmc   +1 more source

A Study on the Mechanism of the Impact of Failed Learning on Enterprise Innovation Performance From the Perspective of Social Information Processing

Creativity and Innovation Management, EarlyView.
ABSTRACT This study investigates the impact mechanism of different dimensions of failure learning on corporate innovation performance. Compared with the extensively researched field in the effects of organizational failure learning, this area remains largely underexplored.
Shiyuan Zhou, Yichao Si
wiley   +1 more source

A Mendelian randomization study exploring the genetic associations between biliary system disorders and brain structural changes. [PDF]

Medicine (Baltimore)
Qu R, Ruan Q, Han R, Li C, Zhao Y, Liang Y, Zhang Y.   +6 more
europepmc   +1 more source

Surfactant-Particle Engineering Hybrids: Emerging Strategies for Enhancing Solubility and Oral Bioavailability of Poorly Water-Soluble Drugs. [PDF]

Pharmaceutics
Kim KS, Cho HJ, Din FU, Cho JH, Choi HG.
europepmc   +1 more source

Patents and New Product Development in the Pharmaceutical and Biotechnology Industries [PDF]

Henry Grabowski
core  

Commentary: Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitis. [PDF]

Front Immunol
Tsai MC, Chen HY, Liao JC, Liu YY, Liu XL, Yong SB, Li CJ.   +6 more
europepmc   +1 more source

Enteric Coating Enhances the Biopharmaceutical Performance of a Silica-Lipid Formulation of Abiraterone Acetate. [PDF]

Pharmaceutics
Taheri A, Almasri R, Wignall A, Feltrin F, Bremmell KE, Joyce P, Prestidge CA.   +6 more
europepmc   +1 more source