Results 161 to 170 of about 244 (211)
Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization
Advanced Science, EarlyView.A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley +1 more source
Advanced Science, EarlyView.Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu +9 more
wiley +1 more source
Editorial: Bridging computation, biophysics, medicine, and engineering in neural circuits
Frontiers in Neural CircuitsKamiya, Haruyuki +4 more
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Advanced Science, EarlyView.We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar +4 more
wiley +1 more source
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insilicoSim: an extendable engine for parallel heterogeneous biophysical simulations
Proceedings of the 3rd International ICST Conference on Simulation Tools and Techniques, 2010Recently, several multidisciplinary projects have begun to model and simulate human physiological systems. However, the simulators for these models are often limited in terms of simulation type and lack of parallel computing support. In this paper we describe insilicoSim, an extendable simulation engine for performing parallel large scale biophysical ...
Yoshiyuki Asai +2 more
exaly +2 more sources
IGARSS 2024 - 2024 IEEE International Geoscience and Remote Sensing Symposium
Haydar Akçay, Elif Sertel
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Haydar Akçay, Elif Sertel
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Cell engineering: Biophysical regulation of the nucleus
Biomaterials, 2020Cells live in a complex and dynamic microenvironment, and a variety of microenvironmental cues can regulate cell behavior. In addition to biochemical signals, biophysical cues can induce not only immediate intracellular responses, but also long-term effects on phenotypic changes such as stem cell differentiation, immune cell activation and somatic cell
Yang, Song +4 more
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Tissue engineering: the biophysical background
Physics in Medicine and Biology, 2001Tissue engineering is the construction, repair or replacement of damaged or missing tissue in humans and other animals. This engineering may take place within the animal body or as tissue constructs to be made in a bioreactor for later grafting into the animal. The minimal set of materials for this are the appropriate types of cell.
A, Curtis, M, Riehle
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Biophysical and engineering aspects of cryosurgery
Physics in Medicine & Biology, 1981A review is presented. Investigations of the techniques and biological results of cryosurgery have considerably advanced the author's understanding of the freezing process in tissues and have enabled cryosurgery to become a powerful and respected tool in the service of medicine.
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Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering
ACS Chemical Biology, 2016The application of the CRISPR-Cas9 system for genome engineering has revolutionized the ability to interrogate genomes of mammalian cells. Programming the Cas9 endonuclease to induce DNA breaks at specified sites is achieved by simply modifying the sequence of its cognate guide RNA.
James K, Nuñez +2 more
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