Results 161 to 170 of about 1,034,839 (324)

Comparing parameter-reduction methods on a biophysical model of an auditory hair cell

Physical Review Research
Biophysical models describing complex cellular phenomena typically include systems of nonlinear differential equations with many free parameters. While experimental measurements can fix some parameters, those describing internal cellular processes ...
Joseph M. Marcinik, Martín A. Toderi, Dolores Bozovic   +2 more
doaj   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Beyond NDVI: Extraction of biophysical variables from remote sensing imagery

, 2014
This chapter provides an overview of methods used for the extraction of biophysical vegetation variables from remote sensing imagery. It starts with the description of the main spectral regions in the optical window of the electromagnetic spectrum based ...
J. G. P. W. Clevers, Clevers, J.G.P.W.
core   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosections

, 2006
We performed second harmonic generation (SHG) imaging of collagen in rat-tendon cryosections, using femtosecond laser scanning confocal microscopy, both in backscattering and transmission geometries.
Theodossiou, Theodossis A., Thrasivoulou, C, Chidi Ekwobi, Ekwobi, Chidi, Theodossiou, TA, Becker, DL, Becker, David L., David L. Becker, Christopher Thrasivoulou, Thrasivoulou, Christopher, Theodossis A. Theodossiou, Ekwobi, C   +11 more
core   +1 more source

Assessment of the impacts of the desertification process in the Western Seridó by biophysical and social indicators

, 2022
O processo de degradação das terras do semiárido está associado às vulnerabilidades ambientais e econômicas relacionadas a fatores de origem natural e principalmente antrópico. Historicamente a microrregião do Seridó Ocidental Paraibano teve a Caatinga como meio de subsistência e fonte de renda.
Esteves, Poliana Maria da Silva Valdevino, Cruz, Fabiano Santiago   +1 more
openaire   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Potential and Limitations of Multi-Temporal Earth Observation Data to Improve Modeled Results of Tree Species Distribution in Mexico

, 2009
The study explored the potential of multi-temporal remote sensing data for distribution modeling of selected tree species belonging to the genera Pinus spp. (pine) and Quercus spp. (white oak) in Mexico. Several environmental predictor data sets at 1
Cord, Anna, Schmidt, Michael, Dech, Stefan   +2 more
core  

UAV-Based Vegetation Indices to Evaluate Coffee Crop Response after Transplanting Seedlings Grown in Different Containers

Agriculture
Brazil stands out among coffee-growing countries worldwide. The use of precision agriculture to monitor coffee plants after transplantation has become an important step in the coffee production chain.
Rafael Alexandre Pena Barata, Gabriel Araújo e Silva Ferraz, Nicole Lopes Bento, Lucas Santos Santana, Diego Bedin Marin, Drucylla Guerra Mattos, Felipe Schwerz, Giuseppe Rossi, Leonardo Conti, Gianluca Bambi   +9 more
doaj   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source