Results 191 to 200 of about 32,154 (264)

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, EarlyView.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Comparative Evaluation of Topical Stabilized Retinaldehyde 0.1% vs. 0.05% on Skin Biophysical and Biomechanical Parameters. [PDF]

Skin Res Technol
Deda A, Odrzywołek W, Lebiedowska A, Banyś A, Bożek M, Kuca D, Wiśniewska N, Wcisło-Dziadecka D, Wilczyński S.   +8 more
europepmc   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

1P013 Some cooperative aspects of protein aggregation phenomena(Protein: Structure,Poster,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

Seibutsu Butsuri, 2014
openaire   +2 more sources

Unveiling New Perspectives on the Hirota–Maccari System With Multiplicative White Noise

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In this study, we delve into the stochastic Hirota–Maccari system, which is subjected to multiplicative noise according to the Itô sense. The stochastic Hirota–Maccari system is significant for its ability to accurately model how stochastic affects nonlinear wave propagation, providing valuable insights into complex systems like fluid dynamics
Mohamed E. M. Alngar, Khaled A. Gepreel, Reham M. A. Shohib, Yakup Yildirim   +3 more
wiley   +1 more source

Current practices in the study of biomolecular condensates: a community comment. [PDF]

Nat Commun
Alberti S, Arosio P, Best RB, Boeynaems S, Cai D, Collepardo-Guevara R, Dignon GL, Dimova R, Elbaum-Garfinkle S, Fawzi NL, Fuxreiter M, Gladfelter AS, Honigmann A, Jain A, Joseph JA, Knowles TPJ, Lasker K, Lemke EA, Lindorff-Larsen K, Lipowsky R, Mittal J, Mukhopadhyay S, Myong S, Pappu RV, Rippe K, Shelkovnikova TA, Vecchiarelli AG, Wegmann S, Zhang H, Zhang M, Zubieta C, Zweckstetter M, Dormann D, Mittag T.   +33 more
europepmc   +1 more source

Weak Solutions for a Class of Nonlocal Singular Problems Over the Nehari Manifold

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In this paper, we consider a nonlocal model of dilatant non‐Newtonian fluid with a Dirichlet boundary condition. By using the Nehari manifold and fibering map methods, we obtain the existence of at least two weak solutions, with sign information.
Zhenfeng Zhang, Calogero Vetro, Tianqing An   +2 more
wiley   +1 more source

The future of Asian biophysics built through Korea-Japan collaboration. [PDF]

Biophys Physicobiol
Song C.
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

A novel methodology to characterize beat-to-beat alternations in whole-cell calcium currents. [PDF]

PLoS One
Marimon X, Cerrolaza M, Tarifa C, Hove-Madsen L.   +3 more
europepmc   +1 more source