Results 341 to 350 of about 42,116 (405)

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Evaluation of Custom Microalgae-Based Bioink Formulations for Optimized Green Bioprinting. [PDF]

Materials (Basel)
Ayowole O, Lapp J, Khoda B.
europepmc   +1 more source

Opportunities of patient‐derived organoids in drug development

British Journal of Pharmacology, EarlyView.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Microgel-based bioink for extrusion-based 3D bioprinting and its applications in tissue engineering. [PDF]

Bioact Mater
Iyer KS, Bao L, Zhai J, Jayachandran A, Luwor R, Li JJ, Li H.   +6 more
europepmc   +1 more source

Revolutionising Cancer Immunotherapy: Advancements and Prospects in Non‐Viral CAR‐NK Cell Engineering

Cell Proliferation, Volume 58, Issue 4, April 2025.
This manuscript provides a comprehensive overview of the state‐of‐the‐art in non‐viral CAR‐NK cell engineering, highlighting its potential to revolutionise cancer treatment. ABSTRACT The recent advancements in cancer immunotherapy have spotlighted the potential of natural killer (NK) cells, particularly chimeric antigen receptor (CAR)–transduced NK ...
Zhaokai Zhou, Yifeng Chen, Yuhao Ba, Hui Xu, Anning Zuo, Shutong Liu, Yuyuan Zhang, Siyuan Weng, Yuqing Ren, Peng Luo, Quan Cheng, Lulu Zuo, Shanshan Zhu, Xing Zhou, Chuhan Zhang, Yukang Chen, Xinwei Han, Teng Pan, Zaoqu Liu   +18 more
wiley   +1 more source

Functional regeneration strategies of hair follicles: advances and challenges. [PDF]

Stem Cell Res Ther
Chu X, Zhou Z, Qian X, Shen H, Cheng H, Zhang J.   +5 more
europepmc   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Establishing a Bioink Assessment Protocol: GelMA and Collagen in the Bioprinting of a Potential <i>In Vitro</i> Intestinal Model. [PDF]

ACS Biomater Sci Eng
Rea M, Lisa LD, Pagnotta G, Gallo N, Salvatore L, D'Amico F, Campilio N, Baena JM, Marchal JA, Cicero AFG, Borghi C, Focarete ML.   +11 more
europepmc   +1 more source

Intelligent Manufacturing for Osteoarthritis Organoids

Cell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley   +1 more source

3D bioprinting for the construction of drug testing models-development strategies and regulatory concerns. [PDF]

Front Bioeng Biotechnol
Mallya D, Gadre MA, Varadharajan S, Vasanthan KS.   +3 more
europepmc   +1 more source