Results 91 to 100 of about 99,881 (284)

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Comparison of Franseen and novel tricore needles for endoscopic ultrasound-guided fine-needle biopsy in a porcine liver model

Scientific Reports
Endoscopic ultrasound-guided fine needle biopsy is an effective method for obtaining tissue samples from various organs; however, challenges such as inadequate specimens persist.
Yubeen Park, Jeon Min Kang, Ji Won Kim, Dong-Sung Won, Dae Sung Ryu, Song Hee Kim, Chae Eun Yun, Seung Jin Eo, Jung-Hoon Park, Sang Soo Lee   +9 more
doaj   +1 more source

Multicentric B-cell lymphoma in a pygmy goat [PDF]

, 2016
A six-year-old, male pygmy goat was referred with a sudden onset of peripheral lymphadenopathy, which initially started as enlarged inguinal lymph nodes. Clinical examination showed swollen retropharyngeal, prescapular and inguinal lymph nodes. Serologic
Chiers, Koen, Deprez, Piet, Kolkman, Iris, Pardon, Bart, Ribbens, Stefaan, Van Aert, Marcel, Versnaeyen, Han   +6 more
core  

Breast cancer risk is increased in the years following false-positive breast cancer screening [PDF]

, 2017
A small number of studies have investigated breast cancer (BC) risk among women with a history of false-positive recall (FPR) in BC screening, but none of them has used time-to-event analysis while at the same time quantifying the effect of false ...
Akl, Alamo-Junquera, Bangsboll-Andersen, Barlow, Blanch, Burrell, Castells, Castells, Christiansen, Ciatto, Duijm, Goossens, Haesook, Haward, Henderson, Hofvind, Marmot, Mathieu, Maxwell, Peeters, Perry, Purushotham, Putter, Verduijn, von Euler-Chelpin, von Euler-Chelpin   +25 more
core   +2 more sources

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Plonos adatos aspiracinė biopsija diagnozuojant skydliaukės vėžį

Lietuvos Chirurgija, 2007
Edita Mišeikytė Kaubrienė1,  Albertas Ulys1, Mantas Trakymas1,  Jolita Rimienė2 1 Vilniaus universiteto Onkologijos institutas, Santariškių g. 1, LT-08660 Vilnius 2 Valstybinis patologijos centras, Santariškių g.
Edita Mišeikytė Kaubrienė, Albertas Ulys, Mantas Trakymas, Jolita Rimienė   +3 more
doaj  

Thyroid Papillary Carcinoma Follicular Variant: Which Surgical Approach?

Haseki Tıp Bülteni, 2014
In general, fine needle aspiration biopsy (FNAB) is insufficient and inadequate in the diagnosis of follicular variant of thyroid papillary carcinoma. Especially in capsulated forms of the carcinoma, diagnostic difficulties are pronounced because of the ...
M. Gazi Yıldız, Sedat Aydın, Arif Şanlı, Mustafa Paksoy, Aylin Ege Gül   +4 more
doaj   +1 more source

Breast cancer or metastasis? An unusual case of metastatic malignant pleural mesothelioma to the breast [PDF]

, 2015
Background: Metastases to the breast from extramammary malignancies are very rare, and ruling out the diagnosis of primary breast tumor is important in order to decide on clinical management and predict prognosis.
Derme, Martina, FRAMARINO DEI MALATESTA, Marialuisa, Iannini, Isabella, Masselli, Gabriele, Pecorella, Irene, Sammartino, Paolo   +5 more
core   +2 more sources

Deep Learning‐Assisted Coherent Raman Scattering Microscopy

Advanced Intelligent Discovery, EarlyView.
The analytical capabilities of coherent Raman scattering microscopy are augmented through deep learning integration. This synergistic paradigm improves fundamental performance via denoising, deconvolution, and hyperspectral unmixing. Concurrently, it enhances downstream image analysis including subcellular localization, virtual staining, and clinical ...
Jianlin Liu, Rujia Liu, Xinyan Zhang, Xun Chen, Shuhua Yue   +4 more
wiley   +1 more source

Forward-Viewing Endoscopic Ultrasound-Guided Fine-Needle Biopsy for a Hypopharyngeal Carcinoma Mimicking a Subepithelial Lesion: A Case Report. [PDF]

DEN Open
ABSTRACT Subepithelial lesions (SELs) of the head and neck have a low diagnostic yield with mucosal biopsy and carry a bleeding risk. Among endoscopic ultrasound–tissue acquisition (EUS‐TA) techniques, fine‐needle biopsy (FNB) provides higher specimen adequacy and diagnostic accuracy than fine‐needle aspiration (FNA).
Otomo K, Takagi T, Wada J, Ishizaki N, Tamazawa K, Suzuki K, Aizawa M, Ogawa H, Suzuki O, Togashi K.   +9 more
europepmc   +2 more sources