Results 141 to 150 of about 29,628 (262)

Calcification and tumour‐infiltrating lymphocytes predict upgrade of human epidermal growth factor 2 (HER2)‐negative ductal carcinoma in situ diagnosed on core needle biopsy

open access: yesHistopathology, Volume 89, Issue 1, Page 122-135, July 2026.
With evolving paradigm in treatment of patient diagnosed with pure ductal carcinoma in situ (DCIS), it is essential to stratify patients at low risk for upgrade to invasive disease at subsequent excision to inform management decisions. When combined with adequate sampling and intrinsic tumour characteristics, tumour microenvironment (TME) features ...
Monalyn Marabi   +6 more
wiley   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

open access: yesChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Prognostic and Predict Value of Peripheral Blood Circulating Tumor Cells Programmed Death‐Ligand 1 Expression and F‐18‐Fluorodeoxyglucose Metabolic Parameters in Patients With Advanced Non‐Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors

open access: yesCancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Purpose To investigate the concordance and correlation between programmed death‐ligand 1 (PD‐L1) expression in tumor tissue and circulating tumor cells (CTCs), explore the intrinsic link between epithelial‐mesenchymal transition (EMT) and PD‐L1 expression in CTCs, and examine the predictive value of FDG metabolic parameters, CTCs and their PD ...
Momo Sun   +4 more
wiley   +1 more source

Metabolic Fingerprinting of Urine Reveals Metabolite Changes in Women With Breast Cancer

open access: yesCancer Medicine, Volume 15, Issue 6, June 2026.
This study uses metabolomics to compare urine, plasma and serum metabolite profiles across breast cancer, benign breast disease, symptomatic and healthy controls. Significant metabolic differences—especially in amino acids—were found between BC and other groups, with moderate correlations across biofluids, suggesting potential for non‐invasive BC ...
Nur Aimi Aliah Zainurin   +9 more
wiley   +1 more source

Preoperative Co‐Mutation of BRAFV600E and TERT Promoter Predicts Tumor Aggressiveness and Recurrence‐Free Survival in Papillary Thyroid Carcinoma

open access: yesCancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background The individual prognostic impacts of BRAFV600E and TERT promoter mutations in papillary thyroid carcinoma (PTC) are established, but the clinical significance of their co‐occurrence, especially when assessed preoperatively, requires further elucidation.
Chang Deng   +4 more
wiley   +1 more source

Right Upper Lobe Pulmonary Spindle Cell Neoplasm With Rhabdoid Differentiation and Spinal Canal Invasion in a 19‐Year‐Old Female: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT We present an unusual case involving a 19‐year‐old female with progressive respiratory distress. Testing revealed pulmonary spindle cell neoplasms with rhabdoid features and spinal cord involvement and infectious complications, emphasizing the importance of multimodal imaging early for rare presentations, histopathological confirmation of ...
Quang Dai La   +7 more
wiley   +1 more source

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