Results 1 to 10 of about 7,520 (138)

Maladaptive Pulmonary Vascular Responses to Chronic Sustained and Chronic Intermittent Hypoxia in Rat

open access: yesAntioxidants, 2021
Chronic sustained hypoxia (CSH), as found in individuals living at a high altitude or in patients suffering respiratory disorders, initiates physiological adaptations such as carotid body stimulation to maintain oxygen levels, but has deleterious effects
Jesus Prieto-Lloret   +7 more
doaj   +1 more source

An Evolutionary Perspective of the Lipocalin Protein Family

open access: yesFrontiers in Physiology, 2021
The protein family of Lipocalins is ubiquitously present throughout the tree of life, with the exception of the phylum Archaea. Phylogenetic relationships of chordate Lipocalins have been proposed in the past based on protein sequence similarities, but ...
Sergio Diez-Hermano   +4 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

open access: yesHepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo   +14 more
wiley   +1 more source

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus

open access: yesActa Neuropathologica Communications, 2023
Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer's disease (AD).
Clara Muñoz-Castro   +14 more
doaj   +1 more source

Physiology and Pathophysiology of Oxygen Sensitivity

open access: yesAntioxidants, 2021
Oxygen is an essential requirement for metabolism in mammals and many other animals. Therefore, pathways that sense a reduction in available oxygen are critical for organism survival.
Robert S. Fitzgerald, Asuncion Rocher
doaj   +1 more source

Machine Learning Representation of Loss of Eye Regularity in a Drosophila Neurodegenerative Model

open access: yesFrontiers in Neuroscience, 2020
The fruit fly compound eye is a premier experimental system for modeling human neurodegenerative diseases. The disruption of the retinal geometry has been historically assessed using time-consuming and poorly reliable techniques such as histology or ...
Sergio Diez-Hermano   +4 more
doaj   +1 more source

Enseñanza no presencial en la carrera Licenciatura en Bioquímica y Biología Molecular ¿Emergencia o permanencia?

open access: yesSerie Científica de la Universidad de las Ciencias Informáticas, 2022
La situación extrema surgida a fines del 2019 debido a la pandemia de la Covid-19 impuso la búsqueda de alternativas para continuar el desarrollo del proceso de enseñanza-aprendizaje en la educación superior.
Georgina Espinosa López   +5 more
doaj   +4 more sources

Coupling of two pools of P2X7 receptors to distinct intracellular signaling pathways in rat submandibular gland

open access: yesJournal of Lipid Research, 2006
The plasma membrane of cells from rat submandibular glands was isolated and extensively sonicated. The homogenate was centrifuged at high speed in a discontinuous sucrose gradient.
Mikel Garcia-Marcos   +9 more
doaj   +1 more source

Entrevista a la Dra. Eva Ortega Paino, Presidente de la Red de Científicos Españoles en el Exterior y directora científica del Biobanco del Centro Nacional de Investigación Oncológicas (CNIO)

open access: yesPrisma Tecnológico, 2022
Doctora en C.C. Químicas por la Universidad Complutense de Madrid en la especialidad de Bioquímica y Biología Molecular. Su carrera científica se sitúa principalmente en Suecia (Universidad de Lund)  y Noruega donde ha trabajado tanto en industria como ...
Aranzazu Berbey Álvarez
doaj   +1 more source

A Model for ERD2 Function in Higher Plants

open access: yesFrontiers in Plant Science, 2020
ER lumenal proteins have a K(H)DEL motif at their C-terminus. This is recognized by the ERD2 receptor (KDEL receptor in animals), which localizes to the Golgi apparatus and serves to capture escaped ER lumenal proteins.
David G. Robinson, Fernando Aniento
doaj   +1 more source

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