Results 101 to 110 of about 9,707 (246)

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

0.5-V High-Order Universal Filter for Bio-Signal Processing Applications

Applied Sciences
In this paper, a novel multiple-input operational transconductance amplifier (MI-OTA) is proposed. The MI-OTA can be obtained by using the multiple-input bulk-driven MOS transistor (MIBD MOST) technique.
Montree Kumngern, Fabian Khateb, Tomasz Kulej, Somkiat Lerkvaranyu   +3 more
doaj   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

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Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

Immune escape mechanisms revealed by multifunctional nanoprobes targeting PD‐L1 in hepatic cancer progression

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The ICGB@Apt nanoprobes are designed to specifically recognize immune checkpoint molecules such as PD‐L1, thereby enabling precise monitoring of the progression from liver cirrhosis to HC. By binding to PD‐L1 on tumor cells, ICGB@Apt visualizes immune escape events and tumor metastasis while simultaneously reflecting the dynamic interaction between ...
Yiteng Meng, Liwen Jing, Yeda Chen, Shenggang Zhan, Feng Xiong, Wenbiao Chen   +5 more
wiley   +1 more source

Robust Individual Circadian Parameter Estimation for Biosignal-based Personalisation of Cancer Chronotherapy

, 2016
In cancer treatment, chemotherapy is administered according a constant schedule. The chronotherapy approach, considering chronobiological drug delivery, adapts the chemotherapy profile to the circadian rhythms of the human organism. This reduces toxicity
Arbaud, Alexandre, Lévi, Francis, Mikut, Ralf, Reischl, Markus, Schott, Benjamin, Stegmaier, Johannes   +5 more
core  

Advances in cholesterol and lipoproteins detection for healthcare: A review

VIEW, EarlyView.
Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta, Somayeh Fardindoost, Azadeh Abdi, Kaveh Yazdani, Longfei Yin, Syamak Farajikhah, Mina Hoorfar, Fariba Dehghani   +7 more
wiley   +1 more source

Extra-mitochondrial ATP synthesis, proton dynamics at the membrane, and mitochondria-derived vesicles: Current findings and considerations

Mitochondrial Communications
Adenosine triphosphate (ATP) is essential for almost all life forms. In our article, we discuss (i) insights into the bioenergetics of ATP generation, including an extended view of proton currents during oxidative phosphorylation (OXPHOS), (ii ...
Alessandro Maria Morelli, Ann Saada, Felix Scholkmann   +2 more
doaj   +1 more source

Quantitative micro‐XRF combined with X‐ray imaging reveals correlations between Zn concentration and dentin tubule porosity across entire teeth

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The combination of calibrated micro‐CT and quantitative micro‐XRF measurement facilitates the correlation of density and composition in the 3D macro‐structure of teeth. Zn concentration in dentin increases by a factor of 10 toward the pulp. Incidentally, the overall density decreases, showing an association between Zn and the dentin tissue porosity ...
Ioanna Mantouvalou, Leona Johanna Bauer, Vinh‐Binh Truong, Yannick Wagener, Frank Förste, Oleksandra Marushchenko, Stephan Werner, Franco Lizzi, Frank Wieder, Timo Wolff, Birgit Kanngießer, Paul Zaslansky   +11 more
wiley   +1 more source

Whole‐transcriptome sequencing analyses identified exosomal circular RNAs in the plasma of pancreatic cancer patients as novel blood‐based biomarkers of disease

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Pancreatic cancer (PaCa) has a poor prognosis, with low resection rates and high relapse rates, highlighting the urgent need for novel diagnostic biomarkers. Here, we performed whole‐transcriptome sequencing of plasma‐derived exosomes from PaCa patients and identified several differentially expressed circular RNAs (circRNAs).
Xiaomeng He, Yang Di, Lixiang Sun, Zhirong Wu, Mengting Luo, Xin Zhang, Huaqin Sun, Wanli Xu, Wenchuan Wu, Boheng Zhang, Jin Wang   +10 more
wiley   +1 more source

Prostate cancer diagnosis using plasma extracellular vesicles isolated via aqueous two‐phase systems

VIEW, EarlyView.
Abstract Prostate cancer (PCa) is the second most prevalent cancer in men, with early detection and precise staging remaining critical for improving outcomes. While PSA tests and biopsies are widely used, they suffer from low specificity and often lead to unnecessary procedures.
Yongmin Kwon, Minyeob Lim, Suyeon Kim, Youngju Seo, Meeyoung Kim, Jiyoul Lee, Jaesung Park   +6 more
wiley   +1 more source