Results 341 to 350 of about 1,464,623 (413)

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

Advanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu‐Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao   +13 more
wiley   +1 more source

Multi-Omics and Functional Insights into Triterpenoid Biosynthesis Pathways in <i>Neopicrorhiza scrophulariiflora</i> (Pennell) D.Y.Hong. [PDF]

Plants (Basel)
Zhou P, Wang J, Li C, Li L, Duan L, Wang W, Liu X, Arshad KT, Liang Y, Zhao Y.   +9 more
europepmc   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Eliciting Clavulanic Acid Biosynthesis: The Impact of <i>Bacillus velezensis</i> FZB42 on the Metabolism of <i>Streptoyces clavuligerus</i> ATCC 27064. [PDF]

Metabolites
Patiño LF, Caicedo-Montoya C, Pinilla-Mendoza L, Cuartas JH, Ríos-Estepa R.   +4 more
europepmc   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

Single-cell and multi-omics integration reveals cholesterol biosynthesis as a synergistic target with HER2 in aggressive breast cancer. [PDF]

Comput Struct Biotechnol J
Tseng TY, Hsieh CH, Liu JY, Huang HC, Juan HF.   +4 more
europepmc   +1 more source

STEROID BIOSYNTHESIS BY SURVIVING TESTICULAR TUMOR TISSUE

, 1955
Herbert H. Wotiz, John W. Davis, Henry M. Lemon   +2 more
openalex   +1 more source

Development and Breeding of Herbicide‐Resistant Sorghum for Effective Cereal‐Legume Intercropping

Advanced Science, EarlyView.
This study identified two SbALS mutations (A93T and S624N) conferring robust herbicide resistance in sorghum, facilitating efficient weed control. Structural analysis revealed that imazamox resistance is mediated by disrupted herbicide binding. Furthermore, 126 imazamox resistant soybean varieties are screened for sorghum‐soybean intercropping ...
Sanyuan Tang, Jiayang Shi, Xuefeng Li, Mingliang Yang, Chao Li, Dan Zhang, Sen Yang, Cuo Mei, Zuyong Luo, Li Zhang, Wanke Zhang, Chunrui Zhang, Chenbo Zhu, Xiaowei Ma, Ran Xia, Yuhang Chen, Jinsong Zhang, Qingshan Chen, Shouyi Chen, Qi Xie, Feifei Yu   +20 more
wiley   +1 more source

Tissue- and Condition-Specific Biosynthesis of Ascorbic Acid in <i>Glycine max</i> L.: Insights from Genome-Wide Analyses of Pathway-Encoding Genes, Expression Profiling, and Mass Fraction Determination. [PDF]

Int J Mol Sci
Aziz S, Germano TA, Sousa Do Nascimento MADS, Dos Santos CP, Arnholdt-Schmitt B, de Miranda MRA, Gomes MMA, Mazorra Morales LM, Ayub RA, Oliveira JG, Costa JH.   +10 more
europepmc   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source