Results 121 to 130 of about 2,128,798 (360)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Current research in biotechnology: Exploring the biotech forefront

open access: yesCurrent Research in Biotechnology, 2019
Biotechnology is an evolving research field that covers a broad range of topics. Here we aimed to evaluate the latest research literature, to identify prominent research themes, major contributors in terms of institutions, countries/regions, and journals.
Andy Wai Kan Yeung   +36 more
doaj  

Biotechnology of Coconut

open access: yesJournal of Horticultural Sciences, 2007
Biotechnology of coconut (Cocos nucifera L.) is a relatively recent area compared to similar work in other crops. It started as tissue culture in the eighties, which led to the development of molecular markers in late nineties with the use of RAPDs ...
V A Parthasarathy   +2 more
doaj   +1 more source

The roles and applications of extracellular vesicles in cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Ethical issues of biotechnological human design

open access: yesRUDN Journal of Philosophy, 2015
Intensive development of biotechnology problematize the boundaries between the phenomenon of technological artifacts and natural objects. Intensive development of biotechnology problematize the boundaries between the phenomenon of technological artifacts
O V Popova
doaj  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Cuba: the strategic choice of advanced scientific development, 1959-2014 [PDF]

open access: yesarXiv, 2016
Cuba is continuing attracting the attention of the international scientific community for some important and unexpected achievements in applied science such as health biotechnology. They represent outcomes of the 1959 decision of Cuba to develop an advanced scientific system in order to address the most urgent problems for the development of the ...
arxiv  

Potential Impacts of Artificial Intelligence (AI) in Biotechnology

open access: yesApplied Sciences
The impact of artificial intelligence (AI) in biotechnology has become increasingly significant, driving advancements across multiple subfields in several areas of science.
Alexandrina Gomes   +5 more
doaj   +1 more source

Stimuliert der BioRegio-Wettbewerb die Bildung von Biotechnologieclustern in Deutschland? [PDF]

open access: yes
Regions with biotechnology-specific knowledge seem to have best chances to attract potential entrepreneurs to establish a biotechnology-firm. Furthermore, regional oriented technology policy is supposed to stimulate the creation process of biotechnology ...
Engel, Dirk, Heneric, Oliver
core  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

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