Results 141 to 150 of about 72,846 (301)

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source

Double winding vine-shaped biphenyl with molecular asymmetry. Synthesis, structure, and properties

A biphenyl derivative in which two benzene rings are strapped with two chains is prepared. The synthesized product shows molecular asymmetry, which was confirmed by HPLC analysis with chiral column and named as winding vine-shaped biphenyl. The synthesis
Atsunori, Mori, Masaki, Horie, Aruto, Maruka, Kohei, Tabuchi, Kentaro, Okano   +4 more
core   +1 more source

Synthesis of Biphenyl-Biphenyl Derivatives as Insulin Mimetics [PDF]

, 2007
This thesis describes the synthesis of some biphenyl-biphenyl analogues for the treatment of diabetes. Researchers at Curtin University of Technology have reported the discovery of small molecule insulin mimetics. One of the reported compounds (IM140) is
Diao, Huixiang
core  

Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes

Drug Testing and Analysis, EarlyView.
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug, S. Guddat, C. Görgens, K. Walpurgis, F. Toma, A. Thomas, M. Thevis   +6 more
wiley   +1 more source

Gas–Solid Interface‐Assisted Growth of Organic Semiconductor Single Crystals: Dimensions, Structures, Mechanisms, and Applications

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Gas–solid interface‐assisted growth strategies have unlocked precise control over crystal structure, morphology, dimension, and molecular packing. The obtained organic semiconductor single crystals represent the ideal candidates for high‐performance organic optoelectronic devices.
Tingyi Yan, Qing Tian, Jinwen Wang, Ke Jiang, Yage Han, Yuanzhuang Ren, Lingyun Li, Xiujuan Zhang, Jiansheng Jie   +8 more
wiley   +1 more source

Molecularly Engineered Dual‐Crosslinked Polymer Dielectrics for 200 °C Capacitive Energy Storage

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work establishes a molecular engineering strategy that constructs a robust dual‐crosslinked network in polymer nanocomposites, achieving a record‐high energy density of 5.17 J cm−3 with >90% efficiency at 200 °C. The multiscale‐validated design simultaneously enhances dielectric polarization and introduces deep electron traps, resulting in ...
Xue Li, Ling Weng, Lizhu Guan, Xiaoming Wang, Ze Li, Xiaorui Zhang, Ruiqun Pan, Yuhan Li, Zijian Wu, Yingtang Zhang   +9 more
wiley   +1 more source

Design, Synthesis, and Photophysical Studies of Functionalized Polyaromatic Isonitriles as Visible Light Photoredox Catalysts

European Journal of Organic Chemistry, EarlyView.
A new series of structurally rich polyaromatic isonitriles is presented as photoredox catalysts. Their photophysical properties are investigated by UV–Vis absorption and fluorescence measurements, combined with experimental and theoretical studies to evaluate both ground‐ and excited‐state redox properties.
Cristina Martini, Camilla Russo, Jussara Amato, Carmine Volpe, Francesca Brunelli, Laurence Grimaud, Maxime R. Vitale, Greta Donati, Andrea Basso, Mariateresa Giustiniano   +9 more
wiley   +1 more source

Dibenzosuberene‐Winged Polycyclic Aromatic Hydrocarbons

European Journal of Organic Chemistry, EarlyView.
The twisted acene 8, which features two dibenzosuberene “wings”, was prepared by the addition of a crowded aryne to a similarly “winged” cyclopentadienone. Compound 8 is chiral, and it has a high barrier to thermal racemization (ΔG‡rac = 36 kcal/mol), but it undergoes fast photochemical racemization even in ambient light.
Mingshu Xie, Xiaodong Zhang, Michael W. Johnson, Robert A. Pascal Jr   +3 more
wiley   +1 more source

Activation of Aryl Halides by Triplet–Triplet Annihilation Upconversion Enabling Coupling Processes Under an Open‐to‐Air Environment

European Journal of Organic Chemistry, EarlyView.
Triplet–triplet annihilation upconversion (TTA‐UC) performed inside supramolecular viscoelastic gels enables efficient CC and C–heteroatom coupling reactions under green LED irradiation in open‐air conditions. The gel network restricts oxygen diffusion, preserves triplet states, and allows aryl halide activation through upconverted excited states ...
Daniel Álvarez‐Gutiérrez, Paola Domínguez Domínguez, M. Consuelo Jiménez, David Díaz Díaz, Raúl Pérez‐Ruiz   +4 more
wiley   +1 more source

Cyclodextrins as Chiral Selectors in Capillary Electrophoresis—Recent Developments in Understanding Analyte Complexation and Applications in Pharmaceutical Analysis

ELECTROPHORESIS, EarlyView.
Cyclodextrins are the most often applied chiral selectors in CE enantioseparations. In combination with NMR spectroscopy and molecular modeling, studies for an understanding of chiral recognition underlying enantioseparations have been performed.
Gerhard K. E. Scriba
wiley   +1 more source