Results 211 to 220 of about 78,578 (289)

One Face, Three Solutions: Structural Convergence in PD-L1 Inhibition across Antibodies, Macrocycles, and Small Molecules. [PDF]

J Med Chem
Capriello I, Moreira Pereira T, Reis GB, Thimmalapura Marulappa V, Magiera-Mularz K, Plewka J, Holak TA, Dömling A.   +7 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Bayesian Optimization of a Suzuki Coupling for the Industrial Synthesis of a Sartan Drug Intermediate. [PDF]

ACS Omega
Molins M, Fernandez-Garcia J, Vázquez D, Berzosa X.   +3 more
europepmc   +1 more source

Enhanced High-Temperature Capacitive Energy Storage in Polynorbornene Nanocomposites Enabled by Functional Side-Chain Groups and Physical Cross-links. [PDF]

Small
Wang Z, Zhong H, Ye J, Ye Z, Chen S.
europepmc   +1 more source

Host resistance modulates in planta efficacy of seed‐applied fluxapyroxad against spot form net blotch in barley

Pest Management Science, EarlyView.
Barley variety influences fluxapyroxad efficacy by affecting distribution and dissipation of the active ingredient, with plant biomass contributing to these differences. Abstract BACKGROUND Seed‐applied fungicides are used to protect barley seedlings from spot form net blotch, caused by Pyrenophora teres f. maculata, among other diseases.
Varthini Govindaraju Punithan, Adam H Sparks, Mark Gibberd, Jordan Campbell, Arundhati Singh, M Jordi Muria‐Gonzalez   +5 more
wiley   +1 more source

YK-4-250, a synthetic telmisartan-tempol conjugate: crystal structure of a stabilized free radical containing an angiotensin AT₁ receptor inhibitor. [PDF]

Acta Crystallogr C Struct Chem
Friedrich S, Kong Y, Musayev FN, Brown ML, Gupton BF.   +4 more
europepmc   +1 more source

In planta fluxapyroxad gradients from seed treatment differentially select fungicide‐sensitive and reduced‐sensitive genotypes of Pyrenophora teres f. maculata

Pest Management Science, EarlyView.
Spatial concentration gradients of seed‐applied fluxapyroxad within barley create heterogeneous exposure environments, driving differential suppression of succinate dehydrogenase inhibitor‐sensitive Pyrenophora teres f. maculata isolates and enrichment of reduced‐sensitive genotypes, thereby shaping within‐host fungicide resistance selection dynamics ...
Arundhati Singh, Elizabeth Czislowski, Mark Gibberd, Kefei Chen, Francisco J Lopez‐Ruiz, M Jordi Muria‐Gonzalez   +5 more
wiley   +1 more source

Using xenon difluoride and 2 Li[Al{OC(CF₃)₃}₄] as an oxidant: from organoxenonium intermediates to (fluoro-)biphenyl radical cations. [PDF]

Chem Sci
Kloiber K, Heizmann T, Lacombe B, Thielert P, Sellin M, Schwandt T, Richert S, Weber S, Krossing I.   +8 more
europepmc   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source