Interaction of brequinar and analogs with PD-L1: a molecular docking analysis [PDF]
Exploration of Drug ScienceAim: The immunosuppressive drug brequinar (BQR) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) active against autoimmune diseases and viral infections.
Gérard Vergoten, Christian Bailly
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Isolation, synthesis and medicinal chemistry of biphenyl analogs – A review
Results in Chemistry, 2023 The scaffold-based drug design has been widely used in new drug discovery. Biphenyl and its analog scaffold are found in many drugs and naturally occurring compounds.
Sandeep Singh, P. Geetha, R. Ramajayam
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1,6-Interactions between dimethylamino and aldehyde groups in two biphenyl derivatives [PDF]
, 2001 The title compounds, 2-(dimethylamino)biphenyl-2'-carboxaldehyde, C15H15NO, and 2-(dimethylamino)biphenyl-2',6'-dicarboxaldehyde, C16H15NO2, show similar 1,6-interactions [N...C=O 2.929 (3) to 3.029 (3) Å] between the dimethylamino and aldehyde groups ...
O'Leary, J, Wallis, JD, Wood, ML
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The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) [PDF]
, 2014 The long-chain fatty acid receptor FFA4(previously GPR120) is receiving substantial interest as a novel target for the treatment of metabolic and inflammatory disease.
Hudson, Brian D. +3 more
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(Biphenyl-2-yl)bromidobis(2-methyltetrahydrofuran-[kappa]O)magnesium(II) [PDF]
, 2009 In the title Grignard reagent, [MgBr(C12H9)(C5H10O)2], the Mg centre adopts a distorted tetrahedral MgCO2Br arrangement. The dihedral angle between the two aromatic rings of the biphenyl residue is 44.00 (14)°. Each molecule incorporates one R- and one S-
Simon Nordschild +5 more
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2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. [PDF]
, 2017 Cytosolic phospholipase A2 (GIVA cPLA2) is the only PLA2 that exhibits a marked preference for hydrolysis of arachidonic acid containing phospholipid substrates releasing free arachidonic acid and lysophospholipids and giving rise to the generation of ...
Barbayianni, Efrosini +10 more
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ChemistryMetal complexes have potential applications in drug discovery due to their unique properties. For example, zinc(II) ions (ZnII) exhibit a high affinity for DNA and have been used as active centers in artificial protein/small-molecule metallonucleases. In
Yoshimi Ichimaru +8 more
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Sphingobium fuliginis HC3: a novel and robust isolated biphenyl- and polychlorinated biphenyls-degrading bacterium without dead-end intermediates accumulation. [PDF]
PLoS ONE, 2015 Biphenyl and polychlorinated biphenyls (PCBs) are typical environmental pollutants. However, these pollutants are hard to be totally mineralized by environmental microorganisms.
Jinxing Hu +8 more
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Enrichment and Identification of Askarel oil (PCB blend) degrading bacteria enriched from landfill sites in Edo State, Nigeria. [PDF]
, 2011 Microbial degradation following aerobic biodegradation is one of the means used by microorganisms for the removal of persistent organic pollutants from the soil. Bacterial species namely: Pseudomonas, Micrococcus Arthrobacter and Acinetobacter capable of
Nwinyi, Obinna
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Acta Crystallographica Section E: Crystallographic CommunicationsIn the title compound, C20H14BrClO3, the dihedral angles between the aromatic ring of the 4-bromo-2-chlorophenyl and the immediate neighbour and second aromatic ring of the biphenyl moiety are 80.59 (2) and 75.42 (2)°, respectively.
B. S. Palakshamurthy +4 more
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