Chemical Constituents From the Leaves of Gagn. and Their Cytotoxic Activity
Natural Product CommunicationsObjective: The ultimate objective of this study was to isolate bioactive compounds from Grewia bulot Gagn. leaves and evaluate their cytotoxicity against a panel of human cancer cell lines.
Ty Viet Pham +7 more
doaj +1 more source
Synthesis and evaluation of biphenyl compounds as kinesin spindle protein inhibitors
, 2013 Kinesin spindle protein (KSP), an ATP-dependent motor protein, plays an essential role in bipolar spindle formation during the mitotic phase (M phase) of the normal cell cycle. KSP has emerged as a novel target for antimitotic anticancer drug development.
Selivanova, Svetlana V. (author) +11 more
core +1 more source
, 2001 We report density functional theory calculations to obtain the optimized structures for the ground state neutral molecule and radical cations for twelve substituted biphenyl compounds.
Lee, CW +3 more
core +1 more source
Design, synthesis and activity evaluation of tetrahydroisoquinoline-based programmed cell death ligand 1 inhibitors. [PDF]
Smart MolBased on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Yu M +15 more
europepmc +2 more sources
On‐Surface Friedel–Crafts Alkylation Through a Stabilized Intermediate Complex
Angewandte Chemie International Edition, EarlyView.On‐surface Friedel–Crafts alkylation is demonstrated on Ag(111) at the single‐molecule level. STM, XPS, and DFT calculations uncover the reaction mechanism and explain the stabilization of the key intermediate, providing insight into noble‐metal‐surface‐mediated Csp3${\rm C}_{sp^{3}}$─Csp2${\rm C}_{sp^{2}}$ coupling. ABSTRACT The incorporation of sp3${\
Paul Schweer +5 more
wiley +1 more source
Formation of Highly Selective Binding Pockets in UiO‐Type MOFs From Bridged Linkers
Angewandte Chemie International Edition, EarlyView.Much room for design: We present a generalizable strategy for precisely modifying UiO‐type Metal‐organic frameworks with functional groups in a site‐specific manner. Through the use of pre‐connected linkers, pocket‐like pores for molecular recognition are generated.
Tobias Hennig +7 more
wiley +1 more source
Reactions of Some Cyclomanganated Compounds with C-Nitroso Compounds, Allenes, and Ketenimines [PDF]
, 2008 eta2-(5-Methoxy-2-acetylphenyl)tetracarbonylmanganese (30) was reacted with 2-methyl-2-nitrosopropane (31) to form 2-acetyl-5-methoxy-N-(tert-butyl)aniline(43) in low yield.
Revell, John Bernard
core
Catalysis by a Metastable Photoswitchable Cage
Angewandte Chemie International Edition, EarlyView.A self‐assembled heteroleptic cage is formed by isomerizing a photoswitchable ligand to its metastable Z‐isomeric form (Z‐1) using green light and combining with a non‐switchable ligand (2) and palladium(II) ions. The metastable [Pd2(Z‐1)2(2)2]4+ cage is an out‐of‐equilibrium self‐assembled catalyst, and can be reversibly assembled and disassembled ...
Simona S. Capomolla +6 more
wiley +1 more source
Recent advances in photocatalytic hydrogen peroxide production
PhotoMat, EarlyView., 2023 We classify the representative photocatalytic materials for photosynthesis of hydrogen peroxide (H2O2) in recent years and discuss the related modification methods in detail, providing inspiration and insights for the future design of photocatalysts for H2O2 production.
Jinyu Yan +4 more
wiley +1 more source
Spatial distribution and risk assessment of polychlorinated biphenyl compounds from open incineration of used medical disposable face masks. [PDF]
Sci RepAdesina OA +6 more
europepmc +1 more source