Results 221 to 230 of about 47,366 (291)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Implications of Maternal Toxicant Effects on Size‐Dependent Fisheries' Management: A Meta‐Analysis

Fish and Fisheries, Volume 27, Issue 4, Page 895-911, July 2026.
Larger, older fish transfer higher mercury and PCB concentrations to their eggs, significantly reducing offspring hatching success, survival and growth rates in contaminated aquatic ecosystems. These findings suggest that the reproductive benefits of big old fat fecund female fish may be compromised by maternal toxicant transfer in polluted waters ...
Brandon M. Sosa, Christopher R. Malinowski, Tomas O. Höök   +2 more
wiley   +1 more source

Ring‐Opening Arylation of Cyclic Diaryliodoniums via Cyclic Triaryliodanes as Aryne Precursors and Dynamic Aryl Reservoirs

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
Cyclic diaryliodonium salts engage aryl Grignard reagents to trigger a self‐propagating aryne–arylation cycle. Transient cyclic triaryliodanes serve as aryne precursors and dynamic aryl reservoirs, delivering iodine‐capped teraryls with predominant meta‐selectivity. The preserved C─I bond enables outward π‐extension or inward recyclization.
Daichi Ikeshita, Mao Atarashi, Naohiko Yoshikai   +2 more
wiley   +2 more sources

Total Synthesis of Isoriccardin C and Isoriccardin D Based on a Hydroxyl-Directed Palladium-Catalyzed Intramolecular C-H Alkenylation. [PDF]

Org Lett
Losada P, Mascareñas JL, Gulías M.
europepmc   +1 more source

Redox‐Active Guanidines

ChemElectroChem, Volume 13, Issue 12, 17 June 2026.
Redox‐active guanidines, comprising guanidino‐functionalized aromatics (GFAs) and redox‐active urea azines (RAAs), are electron donors and strong Lewis and Brønsted bases that are used in several applications. They act as redox‐active ligands in bistable coordination compounds and as reagents in dehydrogenative coupling reactions and proton‐coupled ...
Hans‐Jörg Himmel
wiley   +1 more source

New Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. [PDF]

J Med Chem
Awasthi A, Patel A, Li H, Kang KM, Hardy CD, Ansari A, Nowar R, Hasan ME, Yang S, Poulos TL, Silverman RB.   +10 more
europepmc   +1 more source

Synthesis and Reactivity of Extremely Electron‐Poor Au(III) Complexes Bearing OTf− or NTf2− Ligands

Chemistry – A European Journal, Volume 32, Issue 22, 9 June 2026.
A new family of electron‐poor Au(III) cations bearing bistriflimide or triflate ligands is reported. These cations can undergo direct C─H metalation with simple arenes to give mono‐aryl cations. Subsequent addition of simple halide sources allows for reductive elimination of aryl halides, formally from Ar─H and X−. ABSTRACT The synthesis and structural
Lachlan Barwise, Emily Mulhallen‐Graham, Lachlan J. Moon, Lachlan Sharp‐Bucknall, Miracle I. Ekavhiare, Keith F. White, Jason L. Dutton   +6 more
wiley   +1 more source

Installing Axial Chirality by Atroposelective C(sp³)-H Bond Oxidation. [PDF]

J Am Chem Soc
Borrell M, Galeotti M, Vicens L, Mintz T, Call A, Pappo D, Costas M.   +6 more
europepmc   +1 more source

Templated Bipolar Host Materials for Blue Phosphorescent Organic Light-Emitting Devices with Negligible Efficiency Roll-Offs. [PDF]

Molecules
Huang H, Hua T, Li N, Zhang Y, Huang M, Zhou X, Zhuang S, Xie G.   +7 more
europepmc   +1 more source

o‐Terphenyl‐Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
This study presents the synthesis and binding properties of a new family of o‐terphenyl‐based macrocycles, TP[n] (n = 2‐8). The trimer variant efficiently binds phenylalanine in water with a 10‐fold selectivity compared to other amino acids and aromatic neurotransmitters.
Swapnil Ghule, Sayan Sarkar, Maria Eugenia Pérez‐Ojeda Rodriguez, Mark Spector, Frank Hampel, Evgeny A. Kataev   +5 more
wiley   +1 more source