Results 111 to 120 of about 194,956 (304)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Does the systematic use of stimulus reduction shorten hospitalization in acute mania? A pilot study [PDF]

Psychiatria Fennica, 2017
Objective: Bipolar disorder (BD) is a serious mental disorder causing not only suffering and disability, but also substantial economic burden. Costs of hospitalization represent the largest share of direct illness cost.
Veera Pohjolainen, Hanna Valtonen, Kirsi Suominen, Erkki Isometsä   +3 more
doaj  

A systematic review of DTI studies in Bipolar Disorder

, 2012
Includes bibliographical references.In the last decade, multiple diffusion tensor imaging (DTI) studies have revealed changes in the microstructure of white matter in bipolar disorder.
Nortje, Gareth
core  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Differences in mood instability in patients with bipolar disorder type I and II: a smartphone-based study

International Journal of Bipolar Disorders, 2019
Background Mood instability in bipolar disorder is associated with a risk of relapse. This study investigated differences in mood instability between patients with bipolar disorder type I and type II, which previously has been sparingly investigated ...
Maria Faurholt-Jepsen, Mads Frost, Jonas Busk, Ellen Margrethe Christensen, Jakob E. Bardram, Maj Vinberg, Lars Vedel Kessing   +6 more
doaj   +1 more source

Differential treatment of bipolar disorder with old and new antiepileptic drugs [PDF]

, 1998
Although lithium remains the preferred medication for bipolar disorders, new investigations suggest that only 60 to 80% of patients have a good response with a classical presentation.
Normann, C., Berger, M., Normann, Claus, Langosch, J., Grunze, Heinz, Langosch, Jens, Walden, Jörg, Berger, Mathias   +7 more
core   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Virginia Woolf, neuroprogression, and bipolar disorder

Brazilian Journal of Psychiatry, 2016
Family history and traumatic experiences are factors linked to bipolar disorder. It is known that the lifetime risk of bipolar disorder in relatives of a bipolar proband are 5-10% for first degree relatives and 40-70% for monozygotic co-twins. It is also
Manuela V. Boeira, Gabriela de Á. Berni, Ives C. Passos, Márcia Kauer-Sant’Anna, Flávio Kapczinski   +4 more
doaj   +1 more source

Predictive value of bipolar-spectrum clinical features in a large cohort of fluoxetine treated patients with major depressive disorder

, 2011
Objective: The presence of unrecognized bipolar disorder or “bipolar spectrum” features has been suggested to contribute to poor treatment response in major depressive disorder.
CASAMASSIMA, FRANCESCO
core  

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source