Results 151 to 160 of about 3,489,237 (370)
Advanced Science, EarlyView.Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu +11 more
wiley +1 more source
Parabiosis, Assembloids, Organoids (PAO)
Advanced Science, EarlyView.This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong +5 more
wiley +1 more source
Longitudinal Study of Diagnoses in Children of Women With Unipolar and Bipolar Affective Disorder
, 1990 School-age children of unipolar depressed, bipolar, chronically medically ill, or normal women were diagnosed every 6 months for up to 3 years. Offspring of unipolar women had the highest rates of disorder at all evaluations, but children of bipolar and ...
Adrian, Cheri +3 more
core +1 more source
Correlation between emotion dysregulation and mood symptoms of bipolar disorder: A systematic review and meta‐analysis [PDF]
, 2023 Vincenzo Oliva +17 more
openalex +1 more source
Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source
Advanced Science, EarlyView.Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan +11 more
wiley +1 more source
The effect of dialectical behavior therapy on executive function in patients with a bipolar disorder [PDF]
, 2018 Background: Bipolar disorder is a debilitating psychiatric disorder characterized by recurrent depression, manic and hippomanic episodes. The effect of a dialectical behavior therapy on executive functions in bipolar disorders has not been addressed so ...
Afshari, Behrooz +2 more
core
Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder [PDF]
, 2023 Diogo Pinto +5 more
openalex +1 more source
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Nature, 2009 S. Purcell +6 more
semanticscholar +1 more source
Broadband All‐Optical Memtransistor Based on Organic Cocrystals for Noise‐Robust Motion Recognition
Advanced Science, EarlyView.This work presents an all‐optical synaptic transistor using DTT‐TCNQ organic charge transfer cocrystals, achieving broadband bidirectional modulation (395–808 nm) with highly linear synaptic plasticity (nonlinearity coefficients αp = 0.00191, αd = 0.00305).
Zhaohui Cai +8 more
wiley +1 more source