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Pharmacogenomics of Bipolar Disorder
Pharmacogenomics, 2013Bipolar disorder (BD) is a lifelong severe psychiatric condition with high morbidity, disability and excess mortality. The longitudinal clinical trajectory of BD is significantly modified by pharmacological treatment(s), both in acute and in long-term stages.
SEVERINO, GIOVANNI +7 more
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Anticonvulsants in bipolar disorder
Australian and New Zealand Journal of Psychiatry, 2006Objective: To review the literature on the effectiveness of anticonvulsant drugs in the management of bipolar disorder. Methods: A selective review of the literature. Results: Valproate is an effective drug, alone or in combination, for mania, but has limited benefit in bipolar depression.
Charles L, Bowden, Nancy U, Karren
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The genetics of bipolar disorder
Molecular Psychiatry, 2020Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its genetic basis has proven to be a very challenging endeavor. Genome-Wide Association Studies (GWAS) have transformed our understanding of BD, providing the first reproducible evidence of specific genetic markers and a highly polygenic architecture that ...
Francis James A. Gordovez +1 more
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New Directions for Mental Health Services, 1992
AbstractThe etiology of bipolar disorder (BD) has a complex genetic component; juvenile‐ and adolescent‐onset BD may be expressing the most genotypically severe form of the illness.
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AbstractThe etiology of bipolar disorder (BD) has a complex genetic component; juvenile‐ and adolescent‐onset BD may be expressing the most genotypically severe form of the illness.
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Neurobiology of bipolar disorder
Expert Review of Neurotherapeutics, 2008Bipolar disorder is one of the most severely debilitating of all medical illnesses. It can lead to significant suffering for patients and their families, limit functioning and workplace productivity, and with its risks of increased morbidity and mortality, it is increasingly recognized as a major public health problem.
Andrew R, Newberg +3 more
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Endophenotypes in bipolar disorder†
American Journal of Medical Genetics, 2002AbstractThe search for genes in bipolar disorder has provided numerous genetic loci that have been linked to susceptibility to developing the disorder. However, because of the genetic heterogeneity inherent in bipolar disorder, additional strategies may need to be employed to fully dissect the genetic underpinnings.
Robert H, Lenox +2 more
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Annals of the New York Academy of Sciences, 1986
Suicide, which is both a stereotypic yet highly individualized act, is a common endpoint for many patients with severe psychiatric illness. The mood disorders (depression and bipolar manic-depression) are by far the most common psychiatric conditions associated with suicide.
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Suicide, which is both a stereotypic yet highly individualized act, is a common endpoint for many patients with severe psychiatric illness. The mood disorders (depression and bipolar manic-depression) are by far the most common psychiatric conditions associated with suicide.
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2010
In this chapter, we will attempt to outline the current state of genetic knowledge for bipolar disorder and briefly summarize the main findings from genetic epidemiology studies. We then review the most recent original literature, based largely on genome-wide association study methods. We conclude with some ideas about future directions.
Jens R, Wendland, Francis J, McMahon
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In this chapter, we will attempt to outline the current state of genetic knowledge for bipolar disorder and briefly summarize the main findings from genetic epidemiology studies. We then review the most recent original literature, based largely on genome-wide association study methods. We conclude with some ideas about future directions.
Jens R, Wendland, Francis J, McMahon
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