Results 31 to 40 of about 1,504,706 (262)

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

From Matched Certificates to Related Persons

Historical Life Course Studies, 2020
For the Netherlands, a rich new data source has become available which contains indexed civil certificates for multiple generations of individuals: LINKS.
Rick Mourits, Ingrid K. van Dijk, Kees Mandemakers   +2 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE).
Sarah L. Patterson, Russell Ellyson, Jessica Fitzpatrick, Ghizlane Yaakoubi, Bradley Pearce, S. Sam Lim, Jinoos Yazdany, Laura C. Plantinga   +7 more
wiley   +1 more source

Inclusion of non-viable neonates in the birth record and its impact on infant mortality rates in Shelby County, Tennessee, USA

Pediatric Reports, 2010
Rates of infant death are one of the most common indicators of a population’s overall health status. Infant mortality rates (IMRs) are used to make broad inferences about the quality of health care, effects of health policies and even environmental ...
Bryan Lee Williams, Melina Samar Magsumbol   +1 more
doaj   +1 more source

Dynamically Actuated Reconfigurable Topographical Surface Enables Active Control of Implant‐Associated Infections

Advanced Functional Materials, EarlyView.
A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash, Jihun Lee, J. Scott VanEpps, Sungmin Nam, Jouha Min   +4 more
wiley   +1 more source

Hypothetical errors and plateaus: A response to Newman.

PLoS Biology, 2018
Newman questions recent claims about a plateau in mortality rates for Italians beyond age 105 on the basis of a hypothetical model. His model implies implausibly high error rates for extreme ages.
Kenneth W Wachter
doaj   +1 more source

The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California

The Lancet Regional Health. Americas, 2021
Introduction: Our understanding of the association between coronavirus disease 19 (COVID-19) and preterm or early term birth among racially and ethnically diverse populations and people with chronic medical conditions is limited.Methods: We determined ...
Deborah Karasek, PhD, MPH, Rebecca J. Baer, MPH, Monica R. McLemore, PhD, MPH, RN, FAAN, April J. Bell, PhD, MPH, Bridgette E. Blebu, PhD, MPH, Joan A. Casey, PhD, Kimberly Coleman-Phox, MPH, Jean M. Costello, Jennifer N. Felder, PhD, Elena Flowers, PhD, RN, Jonathan D. Fuchs, MD, MPH, Anu Manchikanti Gomez, PhD, MSc, Kayla Karvonen, MD, Miriam Kuppermann, PhD, MPH, Liang Liang, PhD, Safyer McKenzie-Sampson, MSPH, Charles E. McCulloch, PhD, Scott P. Oltman, MS, Matthew S Pantell, MD, MS, Xianhua Piao, MD, PhD, Aric A. Prather, PhD, Rebecca J. Schmidt, PhD, Karen A. Scott, MD, MPH, FACOG, Solaire Spellen, MPH, Jodi D Stookey, PhD, Martha Tesfalul, MD, Larry Rand, MD, Laura L. Jelliffe-Pawlowski, PhD, MS   +27 more
doaj   +1 more source