Results 71 to 80 of about 21,496 (261)

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Sub-registro de nascimentos vivos hospitalares em área urbana da região sul do Brasil, em 1989

Revista de Saúde Pública
Com o objetivo de avaliar a real situação do Registro Civil, no Município de Maringá, PR, Brasil, foram estudados 4.876 nascimentos vivos ocorridos nos seus hospitais, em 1989, filhos de mulheres nele residentes. São apresentadas as etapas que permitiram
Regina K. Tanno de Souza, Sabina L.D. Gotlieb   +1 more
doaj  

Advanced methods for linking complex historical birth, death, marriage and census data

International Journal of Population Data Science, 2017
Objective Recent years have seen the development of novel techniques for linking complex types of data that contain records about different types of entities, for example bibliographic databases with records about authors, publications, and venues ...
Peter Christen
doaj   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

State Experiences Linking Medicaid Data With Birth Certificates and Other Data Sources. [PDF]

Med Care, 2023
Predmore Z, Heins S, Hoch E, Baxi S, Grigorescu V, Smith S.   +5 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Confiabilidade do Sistema de Informações sobre Nascidos Vivos Hospitalares no Município do Rio de Janeiro, 1999-2001

Cadernos de Saúde Pública
O objetivo deste artigo é avaliar a cobertura e a confiabilidade das variáveis constantes no Sistema de Informações sobre Nascidos Vivos no Município do Rio de Janeiro, valendo-se da análise das Declarações de Nascidos Vivos emitidas pelas unidades ...
Mariza Miranda Theme Filha, Silvana Granado Nogueira da Gama, Cynthia Braga da Cunha, Maria do Carmo Leal   +3 more
doaj  

Validity of parental work information on the birth certificate

BMC Public Health, 2008
Background In the most recent revision (2003) of the U.S. standard certificate of live births, the National Center for Health Statistics recommended that all states collect maternal and paternal usual occupation.
Langlois Peter H, Suarez Lucina, Brender Jean D   +2 more
doaj   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source