Results 31 to 40 of about 63,681 (258)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Staged Shoulder and Elbow Reconstruction in a Child with Obstetric Brachial Plexus Palsy: Six-year Follow-up

African Journal of Paediatric Surgery
The management of obstetric brachial plexus palsy (OBPP) can be challenging, particularly in neglected patients. We report the long-term results of the surgical management of a late-presenting adolescent girl with severe left shoulder and elbow flexor ...
Shady Samir El-Beshry, Ahmad Saeed Aly, Tamer A. El-Sobky   +2 more
doaj   +1 more source

Investigating the Causes of Newborn Injuries in Childbirth Processes in the Cases Referred to the Legal Medical Department of Kohgiluyeh and Boyer Ahmad Provinces During the Years 2010-2020 [PDF]

Armaghane Danesh Bimonthly Journal, 2023
Background & aim: Birth injuries can be defined as a disruption in the function of the baby's body due to adverse events during birth, which can be avoidable or unavoidable.
L Gholami, PS Eslamnik, M Mohammadi Sartang, K Amini, S Afroughi   +4 more
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Ultrasound Diagnosis of Clavicle Fractures in Newborns: A Systematic Review

Children
Background: Fractures of the clavicle are the most common birth injury among newborns. Aim of this systematic review was to provide a comprehensive analysis of the role of ultrasound (US) in diagnosing clavicular fractures in neonates.
Luca Galimberti, Gisella Garbetta, Antonella Poloniato, Rosanna Rovelli, Graziano Barera, Nicola Guindani, Maurizio De Pellegrin   +6 more
doaj   +1 more source

Neonatal Birth Traumas: Risk factors and types

مجلة كلية الطب, 2010
Background: Birth trauma is defined as injury to neonates resulting from mechanical forces (such as compression or traction) during the process of birth.
Numan N. Hameed, Khalid Q. Izzet
doaj   +1 more source

Age in months and birth order in infant nonfatal injuries: A retrospective cohort study

Public Health in Practice, 2020
Objective: To examine the age in months at which infants visited outpatient clinics or emergency rooms for the first time for nonfatal injuries and to identify risk factors for the occurrence of these injuries.
C. Honda, H. Yamana, H. Matsui, S. Nagata, H. Yasunaga, T. Naruse   +5 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

9-Hole Peg Test in Brachial Plexus Birth Injury: What May It Mean from Total Palsy to Upper Trunk Injuries?

Ergoterapi ve Rehabilitasyon Dergisi
Purpose: The aim of our study is to investigate the relationship of the 9-hole-peg test with self-care activities and motor function in brachial plexus birth injury with different injury types.
Tüzün Fırat, Kıvanç Delioğlu
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source