Results 101 to 110 of about 1,917,180 (294)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Early perinatal outcomes in adolescent pregnancy: a Romanian decade of demographic and social change (2011–2012 vs. 2022–2023)

Frontiers in Reproductive Health
BackgroundPregnancy in adolescence disrupts education, perpetuates economic dependence, and contributes to repeated cycles of poverty. Romania continues to report high adolescent birth rates within the European Union.
Laura Mihaela Suciu, Vlăduț Săsăran, Irina Bianca Kosovski, Diana Maria Chiorean, Mihai Muntean, Amalia Făgărășan, Claudiu Mărginean, Irina Prelipcean   +7 more
doaj   +1 more source

THE NATURAL MOVEMENT OF POPULATION IN THE NORTH-WEST REGION OF ROMANIA

Scientific Papers Animal Science and Biotechnologies, 2023
From the perspective of human development indicators during the past 15 years, Region North-West has undergone a series of negative processes, which are the most significant demographic decline due to negative natural growth and increased migration of ...
MANUELA-DORA ORBOI
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effects of the background radiation on radio pulsar and supernova remnant searches and the birth rates of these objects

, 2003
In different directions of the Galaxy the Galactic background radio radiation and radiation of complex star formation regions which include large number of OB associations have different influences on radio pulsar (PSR) and supernova remnant (SNR ...
Allakhverdiev A. O., Aşkin Ankay, Capellaro E., Georgelin Y. M., Green D. A., Guseinov O. H., Guseinov O. H., Haslam C. G. T., Lorimer D. R., Lyne A. G., Oktay H. Guseinov, Sevinç O. Tagieva, Strom R. G., Sunyaev R.   +13 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Cosmic Stellar Birth and Death Rates

, 2006
The cosmic stellar birth rate can be measured by standard astronomical techniques. It can also be probed via the cosmic stellar death rate, though until recently, this was much less precise.
Ahn, Ando, Ando, Beacom, Bionta, Bisnovatyi-Kogan, Clayton, Fukugita, Hirata, Hopkins, John F. Beacom, Krauss, Malek, Milne, Mirizzi, Schiminovich, Strigari, Strigari, Watanabe, Woosley, Yoshida, Zhang, Zhang   +22 more
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The rate of twin birth is declining [PDF]

Ultrasound in Obstetrics & Gynecology, 2021
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source