Results 31 to 40 of about 594,977 (260)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
ECONOMICSThe purpose of the research work is to assess the indicators of innovation, digitalization and knowledge that have an impact on the creative economy. For this purpose, the following indicators were analyzed: total GVA for the creative industry, the share
Bolatbek Yeldos +4 more
doaj +1 more source
EMIGRATION AND ITS GEODEMOGRAPHIC IMPACT IN SLĂNIC MOLDOVA CITY OF BACĂU COUNTY, ROMANIA [PDF]
Studia Universitatis Babeş-Bolyai: Geographia, 2015 Emigration and Its Geodemographic Impact in Slănic Moldova City of Bacău County, Romania. The article talks about emigration from Slănic Moldova, a city from Bacău county, Romania, and its geodemographic impact, using statistical data from Population ...
ANDREEA MORARU, I. MUNTELE
doaj
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The impact of state agglomeration policy on long-term trends of population changes in Russia
RUDN Journal of Public AdministrationThe study analyzes the impact of state agglomeration policy on demographic trends in Russia, with a special focus on the relationship between urbanization and birth rate.
Arseniy M. Sitkovskiy
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Transformace korejské výchovy / Changes in child rearing in Korea
Kulturní Studia, 2020 This paper discusses child rearing in the Republic of Korea. Koreans believe that parenting begins in the prenatal period, when the foetus is first exposed to the influences that shape it.
Kateřina Kolářová
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source