Results 61 to 70 of about 1,627,187 (248)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

No official identity: a data linkage study of birth registration of Aboriginal children in Western Australia

Australian and New Zealand Journal of Public Health, 2016
Objective: Evidence of identity, particularly a birth certificate, is essential to access many rights. However, the births of many Aboriginal Australians are not registered when they are infants.
Alison J. Gibberd, Judy M. Simpson, Sandra J. Eades   +2 more
doaj   +1 more source

Under-reporting of birth registrations in New South Wales, Australia

BMC Pregnancy and Childbirth, 2012
Background To determine the rates of birth registration over a five-year period in New South Wales (NSW) and explore the factors associated with the rate of registration. Methods This is a cross-sectional study using linked population databases.
Xu Fenglian, Sullivan Elizabeth A, Black Deborah A, Jackson Pulver Lisa R, Madden Richard C   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Trends in the completeness of birth registration in Nigeria: 2002-2010

Demographic Research, 2016
Background: Nigeria is a signatory to the Convention on the Rights of the Child, which identifies birth registration as a child's right. However, it is unclear how much progress has been made toward attaining universal birth registration in the country.
Olusesan Makinde, Bolanle Olapeju, Osondu Ogbuoji, Stella Babalola   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Fatores associados à ausência de registro de nascimento em cartório localizado em maternidade do Sistema Único de Saúde, Nova Iguaçu-RJ, 2012

Epidemiologia e Serviços de Saúde
OBJETIVO: analisar os fatores associados à ausência de registro de nascimento em cartório localizado em maternidade do Sistema Único de Saúde no município de Nova Iguaçu-RJ, Brasil.
Maria Isabel do Nascimento, Regina Fernandes Flauzino, Mara Catarina da Cunha, Gemima Pestana Rafael da Silva, Luana Bezerra da Rocha   +4 more
doaj   +1 more source

BIRTH, STILLBIRTH AND DEATH REGISTRATION [PDF]

American Journal of Public Health, 1926
W HAT is necessary to secure satisfactory registration? This question has been solved in part by the practical procedure of Illinois which raised its state birth records in degree of completeness from 60 per cent in 1918 to approximately 95 per cent in 1922, when it was admitted into the birth registration area of the United States.
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source