Results 91 to 100 of about 551,355 (313)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Low birth weight for gestation and airway function in infancy: exploring the fetal origins hypothesis

, 2004
Background: Poor fetal growth has been associated with impaired airway function in adult life, but evidence linking birth weight and airway function in early childhood is sparse.
Lum, S, Costeloe, K, Hoo, AF, Hawdon, J, Stocks, J, Dezateux, C   +5 more
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Multilevel Analysis of Prenatal Care and Birth Weight in Kenya

, 2021
The paper investigates the effect of adequate use of prenatal care on birth weight in Kenya. We estimate a multilevel model controlling for potential sample selection bias, potential endogeneity of prenatal care, and potential unobserved heterogeneity.
Awiti, Japheth Osotsi
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Teen Smoking and Birth Outcomes [PDF]

In the U.S. teen mothers are more likely to give birth to low birth weight babies than non-teen mothers. There is also substantial evidence that smoking is a risk factor correlated with low birth weight.
Erdal Tekin, Sally Wallace, MaryBeth Walker   +2 more
core  

Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age

, 2002
Background: people who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure ...
Shinebourne, EA, Syddall, H.E., Law, CM, Fayers, PM, A.W. Shiell, E.A. Shinebourne, Shinebourne, E.A., Shiell, AW, C.M. Law, Newsome, C.A., Martyn, C.N., M. de Swiet, Newsome, CA, Martyn, CN, de Swiet, M, H.E. Syddall, P.M. Fayers, C.N. Martyn, Syddall, HE, De Swiet, M., Fayers, P.M., C.A. Newsome, Law, C.M., Shiell, A.W.   +23 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Birth Weight and the Dynamics of Early Cognitive and Behavioural Development [PDF]

In this paper we explore the impact of birth weight on children's cognitive and behavioural outcomes using data from the UK Millennium Cohort Study. In order to deal with the endogeneity of birth weight we use an estimator based on the eliminant method ...
Del Bono, Emilia, Ermisch, John
core  

Pathways of the determinants of unfavourable birth outcomes in Kenya [PDF]

, 2003
This paper explores the pathways of the determinants of unfavourable birth outcomes, such as premature birth, the size of the baby at birth, and Caesarean section deliveries in Kenya, using graphical loglinear chain models. The results show that a number
Diamond, Ian, Magadi, Monica, Madise, Nyovani, Smith, Peter   +3 more
core   +1 more source