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Journal of Cardiovascular Pharmacology, 1990
Many patients receiving bisoprolol treatment might also require warfarin or theophylline therapy. Two studies were carried out in healthy volunteers to investigate the possibility that bisoprolol might interact with warfarin or theophylline, both of which have low therapeutic ratios.
Yuet Lewis +3 more
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Many patients receiving bisoprolol treatment might also require warfarin or theophylline therapy. Two studies were carried out in healthy volunteers to investigate the possibility that bisoprolol might interact with warfarin or theophylline, both of which have low therapeutic ratios.
Yuet Lewis +3 more
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Journal of Cardiovascular Pharmacology, 1985
The efficacy of once-daily bisoprolol (10 mg) and atenolol (100 mg) was assessed in 19 patients with stable angina, using a double-blind randomized crossover protocol and computer-assisted treadmill exercise testing with continuous monitoring of leads CM5 and CC5, the test being carried out 22-24 h after the last dose. The mean +/- SEM exercise time on
R. S. Kohli +2 more
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The efficacy of once-daily bisoprolol (10 mg) and atenolol (100 mg) was assessed in 19 patients with stable angina, using a double-blind randomized crossover protocol and computer-assisted treadmill exercise testing with continuous monitoring of leads CM5 and CC5, the test being carried out 22-24 h after the last dose. The mean +/- SEM exercise time on
R. S. Kohli +2 more
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Bisoprolol in chronic heart failure
Hospital Medicine, 2000The evidence for the use of beta-blockers in heart failure is substantial. Latest recommendations and guidelines suggest that most heart failure patients should be on a drug regimen of an angiotensin-converting enzyme inhibitor, diuretic and a beta-blocker.
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Balanced Pharmacokinetics and Metabolism of Bisoprolol
Journal of Cardiovascular Pharmacology, 1985Bisoprolol exhibits a high absolute bioavailability (90%) because of its nearly complete absorption (greater than 90%) and small first-pass effect (10%). Bioavailability is independent of food intake. A long plasma-elimination half-life (10-11h) allows a once-a-day dose regimen.
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Self-Poisoning with the β-Blocker Bisoprolol
Human & Experimental Toxicology, 1990A case of bisoprolol self-poisoning resulting in full recovery of the patient is described. The peak plasma level of bisoprolol was 541 ng ml-1. Sinus bradycardia was the only symptom observed, suggesting that cardioselectivity and absence of membrane stabilizing activity contribute to reduce the severity of β-blocker intoxication.
Pascal Kintz +3 more
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Bisoprolol in the Treatment of Chronic Stable Angina Pectoris
Journal of Cardiovascular Pharmacology, 1990The purpose of the study was to assess the efficacy and tolerance of the beta1-selective beta-adrenoceptor-blocking agent bisoprolol in patients with chronic stable angina pectoris. A total of 236 outpatients (158 male and 78 female) over 21 years of age (mean age of 57 years and 60 years for men and women, respectively) were included in an open trial ...
I Terol, L Plaza, F Rodrigo
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Journal of Cardiovascular Pharmacology, 1985
The aim of this study was to investigate the haemodynamics of the beta 1-selective beta-blocker bisoprolol at plasma concentrations that would be expected to block completely the cardiac beta-receptors. Seven patients with stable exercise-dependent angina pectoris received 40 mg bisoprolol, and six patients received 10 mg bisoprolol orally as a single ...
Bonelli J, Staribacher H
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The aim of this study was to investigate the haemodynamics of the beta 1-selective beta-blocker bisoprolol at plasma concentrations that would be expected to block completely the cardiac beta-receptors. Seven patients with stable exercise-dependent angina pectoris received 40 mg bisoprolol, and six patients received 10 mg bisoprolol orally as a single ...
Bonelli J, Staribacher H
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Microbial metabolism of the \-adrenoreceptor antagonist bisoprolol
Applied Microbiology and Biotechnology, 1993Eighteen filamentous fungi and six actinomycetes species were screened for their ability to metabolize bisoprolol, a beta-blocking drug. All strains of Cunninghamella tested accumulated metabolite M4 = EMD 46193 ([4-(2-hydroxy-3-isopropylaminopropoxy)benzyloxy]ethanol).
Hans-Eckart Radunz +2 more
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Wirtschaftlichkeit von Bisoprolol bei Herzinsuffizienz
Medizinische Klinik - Intensivmedizin und Notfallmedizin, 1997The Cardiac Insufficiency Bisoprolol Study (CIBIS) demonstrates that, for patients with heart failure of different etiologies, the administration of the beta(1)-adrenoceptor blocker bisoprolol adjuvant to the standard therapy leads to a significant avoidance of hospital admissions.The results of the CIBIS were evaluated pharmacoeconomically for the ...
Peter K. Schädlich +2 more
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No benefit from bisoprolol for COPD
Drug and Therapeutics BulletinAbstract Overview of: Devereux G, Cotton S, Nath M, et al. Bisoprolol in patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS randomized clinical trial. JAMA. 2024;332:462–70.
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