Results 111 to 120 of about 121,715 (299)

An Alternative Approach to BIST Sustainability Index: An Estimation via Financial Indicators

open access: yes, 2021
Bu araştırmada, BİST Sürdürülebilirlik Endeksi’nde yer alan firmaların alternatif yöntem olarak finansal göstergeleri kullanılarak sürdürülebilirlik endeksi tahmin edilmiş ve mevcut sürdürülebilirlik endeksi ile önerilen yöntem sonucu elde edilen endeks değerleri karşılaştırılarak daha objektif ve kolay hesaplanabilir bir endeks elde edilip ...
KÖSE, Eda; NEVŞEHİR HACI BEKTAŞ VELİ ÜNİVERSİTESİ   +2 more
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Strategic Analyses of the National River Linking Project (NRLP) of India, Series 4. Water productivity improvements in Indian agriculture: potentials, constraints and prospects [PDF]

open access: yes
Water productivityWater use efficiencyMultiple useIrrigation practicesIrrigation systemsWater qualityWater allocationCerealsCrop yieldLivestockMilk productionEconomic ...
Amarasinghe, Upali A., Kumar, M. Dinesh
core  

A Sectoral Overview on the Integrated Reporting Practices in Turkey [PDF]

open access: yes
In Turkey, it has become an obligatory practice for companies listed in Borsa Istanbul (BIST), brokerage firms and portfolio management companies to make financial reporting in the period starting from 2005. Financial reporting means that companies share
Erbuğa, Gökçe Sinem   +1 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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