Results 141 to 150 of about 121,715 (299)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of Corporate Governance on Firms’ Sustainability Performance: Case Study of BIST 50 Index Companies

open access: yesSustainability
Purpose: the purpose of this study is to investigate whether corporate governance mechanisms and attributes influence the sustainability performance of companies included in the BIST 50 Index. Results and contributions: Regression analysis showed that there was a significant positive influence of board tenure on sustainability performance and all its ...
Serhii Lehenchuk   +4 more
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Strategic Analyses of the National River Linking Project (NRLP) of India, Series 1. India’s water future: scenarios and issues [PDF]

open access: yes
River basinsEnvironmental flowsDevelopment projectsWater requirementsIrrigated farmingWater demandFood demandGroundwater irrigationIrrigation efficiencyWater harvestingSupplemental irrigationWater productivityWater conservationDrip irrigationSprinkler ...
Amarasinghe, Upali A.   +2 more
core  

Corporate Governance and Firm Performance: Recent Evidence from Borsa Istanbul (BIST) Corporate Governance Index (XKURY) [PDF]

open access: yes, 2015
As competition for foreign and domestic investment increases, firms look for new ways to remain competitive in today's complex business environment.  Good corporate governance is rewarded with higher market valuation and companies with better corporate ...
Aydin, Alev Dilek, Ozcan, Ahmet
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

New Ruthenium-Cyclopentadienyl Complexes Affect Colorectal Cancer Hallmarks Showing High Therapeutic Potential. [PDF]

open access: yesPharmaceutics, 2023
Brás AR   +7 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

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