Results 141 to 150 of about 448 (260)

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

A Fuzzy Inference Model Proposal for ESG Scores Measurement of BIST Sustainability 25 Index Companies

open access: yes
Environmental, Social, and Governance (ESG) criteria have become essential indicators that not only assess a firm’s sustainability performance but also directly influence long-term financial success, risk management processes, and stakeholder trust.
ÇEBİ, Selçuk, Bolukbasi, Ismail Bugra
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Does Being Included in The Sustainability Index Affect Financial Performance and Firm Value? Evidence From Borsa Istanbul

open access: yes
This study investigates the effect of being included in the Borsa Istanbul Sustainability Index on financial performance and firm value. The company data contained in the BIST Sustainability Index for 2018Q1-2023Q3 are analysed with the Driscoll-Kraay ...
Yilmaz-Ozekenci, Sureyya   +1 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Sürdürülebilirlik endeksi kapsamına alınmanın hisse senedi değerine etkisi: BIST uygulaması

open access: yes, 2018
Bu çalışmanın amacı BİST firmalarının BİST Sürdürülebilirlik Endeksi oluşturulduktan sonra bu endekse dâhil edilmesiyle hisse senedi değerlerinde bir değişim yaşanıp yaşanmadığını incelemektir.
Gündüz, Çağdaş
core  

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