Results 41 to 50 of about 732,700 (303)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Las nuevas tecnologías y el cerebro del futuro [PDF]

open access: yes, 2018
Bit&Byte dialogó con el Dr. Facundo Manes y con el Dr.
Bit & Byte
core  

Two research contributions in 64-bit computing: Testing and Applications

open access: yes, 2005
Following the release of Windows 64-bit and Redhat Linux 64-bit operating systems (OS) in late April 2005, this is the one of the first 64-bit OS research project completed in a British university.
Chang, Victor
core   +1 more source

Experiments and Investigations for the Personal High Performance Computing (PHPC) built on top of the 64-bit processing and clustering systems [PDF]

open access: yes, 2006
The motivation and objective for this paper is to demonstrate “Personal High Performance Computing (PHPC)”, which requires only a smaller number of computers, resources and space in the secure wireless home networking (WHN) environment. The PHPC is based
V. Chang, Chang, V., Chang, Victor
core   +2 more sources

Numerical Analysis for Mechanical Properties of Bundled Integrate Structure Joints

open access: yesChengshi guidao jiaotong yanjiu
[Objective] The U-BIT (underground bundled integrate tunnel) method can solve the problems of steel pipe sections inability in collaborative work and poor support efficiency of the traditional pipe curtain method.
JI Maojie   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Study on Thermal Energy Conversion Theory in Drilling Process of Coal and Rock Mass with Different Stresses

open access: yesEnergies, 2019
In view of the problem that the evolutionary mechanism of bit temperature during the drilling process is still unclear and the influencing factors are complex, this paper analyzes the causes of heat generation and the factors of heat production when the ...
Pengqi Qiu   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Desarrollos tecnológicos [PDF]

open access: yes, 2016
Bit&Byte destina este espacio para compartir con sus lectores algunas de las innovaciones tecnológicas que se han desarrollado en diferentes países del mundo durante los primeros meses del año.Facultad de ...
Bit&Byte, Bit & Byte
core  

Home - About - Disclaimer - Privacy