Results 41 to 50 of about 376,194 (261)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Method for Applying the Use of a Smart 4 Controller for the Assessment of Drill String Bottom-Part Vibrations and Shock Loads

Vibration
Optimization of drilling processes for oil and gas and geothermal wells requires the effective use of mechanical energy for the destruction of rocks.
Serhii Landar, Andrii Velychkovych, Liubomyr Ropyak, Andriy Andrusyak   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Role of the Equestrian Professional in Bridle and Bit Fit in the United Kingdom

Animals
To ensure the comfort of ridden horses, equipment including bridles and bits should be suitable and fit correctly. Horse owners employ a variety of equestrian professionals with varying degrees of responsibility regarding bridle and bit fit.
Kathryn Nankervis, Jane M. Williams, Diana Fisher, Russell MacKechnie-Guire   +3 more
doaj   +1 more source

Bit by Bit

AJN, American Journal of Nursing
Bit by Bit is a visual exploration of e-paper display alongside thoughts and reflections on the relationship we build with the tools and interfaces that surround us. 
openaire   +4 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Un parcours de collectionneur privé « chalinologue »

In Situ, 2015
A ‘chalinologue’, a private collector of horses’ bits. Monsieur Desclos is a passionate collector of old bits, particularly interested in the technology of bits and by ‘system’ bits. He has accumulated a considerable collection, along with associated and
Pierre-Marie Desclos
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Research and Development of PDC Bits for Geothermal Well Drilling

Journal of MMIJ
Polycrystalline diamond compact (PDC) bits, which are widely used in oil and gas well drilling, have begun to be used in geothermal well drilling. Mitsubishi Materials Corporation, K. Maikai Co., Ltd, and National Institute of Advanced Industrial Science
Kuniyuki MIYAZAKI, Takashi TAKEHARA, Masahiro YANO, Tetsuomi MIYAMOTO, Masatoshi TSUZUKI   +4 more
doaj   +1 more source