Results 71 to 80 of about 99 (99)

An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum

Advanced Science, EarlyView.
This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang, Xiaochen Xie, Fuyong Huang, Qiang Wei, Tianxin Cai, Na Yu, Shi Chen, Fei Wang, Wanping Chen, Chin‐yu Chen, Chunhua Li, Lixin Ma   +11 more
wiley   +1 more source

All‐Electrical Control of Spin Synapses for Neuromorphic Computing: Bridging Multi‐State Memory with Quantization for Efficient Neural Networks

Advanced Science, EarlyView.
This study develops three all‐electrically controlled, field‐free spintronic synapse devices for neuromorphic computing. The tilted anisotropy device achieves an 11‐state memory with minimal cycle‐to‐cycle variation (2%), enabling high‐accuracy neural network quantization (81.51% in ResNet‐18). These findings position spintronic synapses as a promising
Tzu‐Chuan Hsin, Chun‐Yi Lin, Po‐Chuan Wang, Chun Yang, Chi‐Feng Pai   +4 more
wiley   +1 more source

Programmable Metamaterials with Perforated Shell Group Supporting Versatile Information Processing

Advanced Science, EarlyView.
This study proposes a novel mechanical metamaterial with high‐density memory based on multi‐stable perforated shells to realize multi‐layer information encoding, storage, decoding, and reading. The metamaterial can perform more application‐oriented tasks to process information, such as encryption and dynamic behavior regulation, which hopefully enables
Xiaoyuan Ma, Ziran Wang, Weipeng Zhang, Peng Yan   +3 more
wiley   +1 more source

Natural Crystal Structure for Generating Raman‐Like Orbital Angular Momentum States

Advanced Science, EarlyView.
This work proposes a strategy for symmetry breaking of the degenerate OAM states relying on the natural anisotropy of crystal gain, to select the handedness of the spatial spiral phase front and further tunable Raman‐like OAM states by thermal‐driven, which clarifies the contribution of intrinsic crystal property to the OAM states and opens a new route
Tianxiang Meng, Changsheng Zheng, Yongguang Zhao, Haohai Yu, Huaijin Zhang   +4 more
wiley   +1 more source

Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model

Advanced Science, EarlyView.
Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis, Elena Capitanini, Karen Kira, Claudia Dell'Amico, Jun Takahashi, Marco Onorati, Fabian Raudzus, Vittoria Raffa   +7 more
wiley   +1 more source

Encapsulation of Metal Nanoparticles by Metal–Organic Framework Imaged with In Situ Liquid Phase Transmission Electron Microscopy

Advanced Science, EarlyView.
In situ liquid‐phase transmission electron microscopy (LP‐TEM) study reveals the pathways through which metal‐organic frameworks (MOFs) encapsulate metal nanoparticles (NPs) and explains why some MOF shells of NP&MOF nanostructures are uniform and single crystalline, while others are nonuniform and polycrystalline.
Guoming Lin, Utkur Mirsaidov
wiley   +1 more source

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

Tailored 3D Lattice Microstructures for Enhanced Functionality in Blood‐Gas Exchange

Advanced Science, EarlyView.
Common hollow fiber structures are associated with inhomogeneous flow, leading to many complications in the medical application of extracorporeal membrane oxygenation. Using locally adapted lattice structures, the overall flow distribution can be manipulated.
Kai P. Barbian, Teresa Lemainque, Ina Grunden, Roman Iwa, Bettina Wiegmann, John Linkhorst, Matthias Wessling, Jan Heyer, Ulrich Steinseifer, Michael Neidlin, Sebastian V. Jansen   +10 more
wiley   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source