Results 81 to 90 of about 99 (99)

Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System

Advanced Science, EarlyView.
This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao, Wanglu Li, Kaiyu He, Hongmei Wang, Yan Xu, Qun Wu, Liu Wang, Yao Nie   +7 more
wiley   +1 more source

High‐Gain PMMA‐Modified Graphene Photodetectors for Dual‐Wavelength Secure Communication Utilizing Distinct Temporal Photoresponses

Advanced Science, EarlyView.
The bipolar photoresponses with temporally distinguishable characteristics in a PMMA‐modified graphene photodetector are successfully achieved. Through systematic harnessing of these wavelength‐dependent temporal dynamics as encrypted and key signals, an effective encryption system for optical communication systems is developed.
Jinhua Wu, Hao Sun, Ruiling Zhang, Shipeng Yao, Zhangyu Hou, Cun‐Zheng Ning   +5 more
wiley   +1 more source

Laser‐Induced Co‐Doped FePS3 with Massively Phosphorus Sulfur Vacancies Nanosheet for Efficient and Highly Stable Electrocatalytic Oxygen Reaction

Advanced Science, EarlyView.
DFT‐guided defect engineering in 2D FePS3 reveals S/P vacancies Co‐doped and exposed Fe sites synergistically enhance OER performance. Laser‐ablation‐induced (Fe0.53Co0.46)PS3 exhibits excellent OER performance (288 mV overpotential, 58.3 mV dec−1 Tafel slope) and outstanding stability (138 h at 10 mA cm−2, 27h at 100 mA cm−2).
Ruiqi Xu, Guoshuai Fu, Weimi Ding, Yifan Li, Guowei Yang, Peng Yu, Shuang Li, Pu Liu   +7 more
wiley   +1 more source

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, EarlyView.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source

Mercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus

Advanced Science, EarlyView.
This study developes a universal colorimetric ICA platform that integrates broad‐spectrum recognition by 4‐mercaptophenylboronic acid with dual signal enhancement—both colorimetric and catalytic—mediated by a biomimetic magnetic nanozyme. This platform, for the first time, enables simple, convenient, ultrasensitive, and simultaneous screening of ...
Qing Yu, Jiaxuan Li, Shuai Zheng, Yajin Hu, Benshun Tian, Meirou Lu, Bing Gu, Chongwen Wang   +7 more
wiley   +1 more source

Mixed‐Dimensional Floating Gate Phototransistors for Mixed‐Modal In‐Sensor Reservoir Computing

Advanced Science, EarlyView.
Designing bio‐inspired multisensory neuromorphic devices holds significant importance for low‐power and high‐efficiency computing. Here, the authors introduce a floating‐gate phototransistor based on the mixed‐dimensional heterostructure of 0D‐CsPbBr3 QDs and 2D‐MoS2 few layers.
Weilun Ouyang, Qirui Zhang, Jiangang Chen, Xiao Luo, Xuemei Wang, Yingying Chen, Fan Yang, Qi Nie, Qing Liu, Fucai Liu   +9 more
wiley   +1 more source

Self‐Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐propelled nanomedicine delivery system forms DMCU nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease‐driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti‐bladder cancer ...
Lei Peng, Anguo Zhao, Rongkang Li, Yujun Liu, Daitian Tang, Dashi Deng, Qi Zhuang, Rui Liang, Shaohua Zhang, Song Wu   +9 more
wiley   +1 more source

Real‐Time Self‐Optimization of Quantum Dot Laser Emissions During Machine Learning‐Assisted Epitaxy

Advanced Science, EarlyView.
This work presents a machine learning‐driven approach integrated with in situ high‐energy electron diffraction (RHEED) monitoring to automate the optimization of quantum dot (QD) growth for lasers. A 3.2‐fold increase in photoluminescence intensity is achieved alongside a narrow spectral linewidth.
Chao Shen, Wenkang Zhan, Shujie Pan, Hongyue Hao, Ning Zhuo, Kaiyao Xin, Hui Cong, Chi Xu, Bo Xu, Tien Khee Ng, Siming Chen, Chunlai Xue, Zhanguo Wang, Chao Zhao   +13 more
wiley   +1 more source

Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1

Advanced Science, EarlyView.
Through elaborate design, a biodegradable scaffold with excellent mechanical properties and suitability is fabricated, providing spatial support for subsequent physiological activities. The prepared GA‐HBC‐LIC hydrogel possesses sequential antibacterial, antioxidant, anti‐inflammatory and immunomodulatory functions, offering a suitable chemical and ...
Jiafei Chen, Xiaoxu Guan, Lina Chen, Bingzhu Zheng, Feiyu Li, Chao Fang, Yike Fu, Xiang Li, Huiming Wang, Yi Zhou   +9 more
wiley   +1 more source