Results 221 to 230 of about 5,335 (248)

Epidemiology and trends of animal bites in Khoy County, Northwest Iran: A retrospective study (2021-2024). [PDF]

PLoS One
Shahmirzalou P, Ebrahimpour Sadagheyani H.   +1 more
europepmc   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Development and validation of an early prediction model for bee-sting-induced acute kidney injury using machine learning. [PDF]

Ren Fail
Fang Y, Zhang J, Hu Z, Yu X, Xie Y, Liu Y, Wu H.   +6 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Necrosis as a reaction to a wasp sting: a case report. [PDF]

Rev Inst Med Trop Sao Paulo
Carvalho AAU, Mendes JVP, Hirsch C, Melo MDT.   +3 more
europepmc   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Poisoning Epidemiology, Clinical Outcomes and Management Decisions for General Public Calls: A Cross-Sectional Analysis of a Nationwide Telehealth Toxicology Consultation Service Data in Saudi Arabia. [PDF]

J Epidemiol Glob Health
Alharbi AA, Muaddi MA, Binhotan MS, Alqassim AY, Alsultan AK, Arafat MS, Aldhabib A, Alaska YA, Alwahbi EB, Almutairi MA, Alharthi M, Khan MM, Alabdulaali M, Aljerian NA.   +13 more
europepmc   +1 more source

Wild and Domestic Animal Exposure among Deceased Persons Referred for Organ Procurement, United States. [PDF]

Emerg Infect Dis
McCormick DW, Lynch R, Doby B, Laskey S, Annambhotla P, Wallace RM, Bonaparte SC, Hicks LA, Basavaraju SV, Kracalik I.   +9 more
europepmc   +1 more source

Digital Health Apps and Web-Based Platforms to Support the Prevention and Management of Snakebite Envenoming: Scoping Review. [PDF]

JMIR Mhealth Uhealth
Hosemann D, Gries O, Rae JD, Tran TV, Sprengholz P, Korn L, Pham TTT, Dang TAT, Kreuels B.   +8 more
europepmc   +1 more source