Results 61 to 70 of about 7,108 (196)

"True" as Ambiguous [PDF]

, 2007
In this paper, I argue (a) that the predicate “true” is ambiguously used to express a deflationary and a substantial concept of truth and (b) that the two concepts are systematically related in that substantial truths are deflationary truths of a certain
Kolbel, Max
core   +1 more source

Linearism, Universalism and Scope Ambiguities

Analytic Philosophy, Volume 67, Issue 1, Page 59-71, March 2026.
ABSTRACT In this paper, I distinguish two possible families of semantics of the open future: Linearism, according to which future tense sentences are evaluated with respect to a unique possible future history, and Universalism, according to which future tense sentences are evaluated universally quantifying on the histories passing through the moment of
Aldo Frigerio
wiley   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

A Generalized Minimal PBPK‐PD Model of Bispecific Antibodies: Case Studies and Applications in Drug Development

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Bispecific antibodies (bsAbs), for which each arm binds a distinct molecular target, are developed to engage soluble and cell surface targets in different therapeutic indications. Three key examples of mechanisms of action (MoA) for bsAbs are (1) immune cell engagers that foster immune cell interactions with target cells, (2) bispecifics that ...
Phillip Spinosa, Louis Joslyn, Saroja Ramanujan, Kapil Gadkar, Iraj Hosseini   +4 more
wiley   +1 more source

Negation and Dichotomy [PDF]

, 2009
The present contribution might be regarded as a kind of defense of the common sense in logic. It is demonstrated that if the classical negation is interpreted as the minimal negation with n = 2 truth values, then deviant logics can be conceived as ...
Schang, Fabien
core   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

Fractional Kinetic Modelling of the Adsorption and Desorption Processes From Experimental SPR Curves

Journal of Chemometrics, Volume 40, Issue 1, January 2026.
ABSTRACT The application of surface plasmon resonance (SPR) has transformed the study of interactions between a ligand immobilized on the surface of a sensor chip (LS$$ {L}_S $$) and an analyte in solution (A$$ A $$). This technique enables the real‐time monitoring of binding processes with high sensitivity. The adsorption–desorption dynamics, A+LS→ALS$
Higor V. M. Ferreira, Nelson H. T. Lemes, Yara L. Coelho, Luciano S. Virtuoso, Ana C. dos Santos Pires, Luis H. M. da Silva   +5 more
wiley   +1 more source

Semantic externalism without thought experiments [PDF]

, 2017
Externalism is the thesis that the contents of intentional states and speech acts are not determined by the way the subjects of those states or acts are internally. It is a widely accepted but not entirely uncontroversial thesis.
Yli-Vakkuri, Juhani
core   +1 more source

Super‐Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation

Advanced Science, Volume 12, Issue 45, December 4, 2025.
A novel chromatin‐labeling probe is developed to investigate chromatin mobility during differentiation. The silicon rhodamine–conjugated dCTP is efficiently delivered into iPSCs and NSCs using a synthetic transporter. Super‐resolution microscopy and single‐particle tracking show decreased chromatin mobility during differentiation.
Maruthi K. Pabba, Miroslav Kuba, Tomáš Kraus, Kerem Celikay, Janis Meyer, Sunil Kumar Pradhan, Andreas Maiser, Hartmann Harz, Heinrich Leonhardt, Karl Rohr, Michal Hocek, M. Cristina Cardoso   +11 more
wiley   +1 more source

Is Aristotle’s Response to the Argument for Fatalism in De Interpretatione 9 Successful?

Ideas y Valores, 2014
The goal of this paper is to figure out whether Aristotle’s response to the argument for fatalism in De Interpretatione 9 is a success. By “response” it is meant not simply the reasons Aristotle offers to highlight why fatalism does not accord with how ...
M. A. Istvan Jr.
doaj