Results 41 to 50 of about 538,072 (320)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Global Projection of Flood Risk With a Bivariate Framework Under 1.5–3.0°C Warming Levels

Earth's Future
Global warming increases the atmospheric water‐holding capacity, consequently altering the frequency, and intensity of extreme hydrological events.
Xi Huang, Jiabo Yin, Louise J. Slater, Shengyu Kang, Shaokun He, Pan Liu   +5 more
doaj   +1 more source

Description of the Joint Probability of Significant Wave Height and Mean Wave Period

Journal of Marine Science and Engineering, 2022
The bivariate probability distribution of significant wave heights and mean wave periods has an indispensable guiding role in the implementation of offshore engineering, which has attracted great attention.
Mingwen Zhao, Xiaodong Deng, Jichao Wang
doaj   +1 more source

Exam‐level analysis of lecture capture viewing and student exam performance

FEBS Open Bio, EarlyView.
This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley   +1 more source

Healthcare outcomes for unsheltered persons experiencing homelessness using a street medicine model of care: a pilot program evaluation

Cogent Social Sciences
Unsheltered homelessness is associated with a myriad of barriers including unmet medical, mental health, physical, and social needs. This study evaluated a Street Medicine approach to examine and reduce the complex barriers to care by providing ...
Linda K. Perna, Camille Patterson, Amy A. Chairez, Jenny Lewis, Jacqueline Jordan, Hajah Komara, Harper Harris   +6 more
doaj   +1 more source

Joint spatial modelling of disease risk using multiple sources: an application on HIV prevalence from antenatal sentinel and demographic and health surveys in Namibia

Global Health Research and Policy, 2017
Background In disease mapping field, researchers often encounter data from multiple sources. Such data are fraught with challenges such as lack of a representative sample, often incomplete and most of which may have measurement errors, and may be ...
D. Ntirampeba, I. Neema, L. N. Kazembe
doaj   +1 more source

Bivariate analysis of typical hydrological series of the yellow river [PDF]

International Journal of Computational Intelligence Systems, 2014
This paper uses Gumbel-Hougaard (G-H) copula, Clayton copula and Frank copula to construct joint distributions of hydrological variables of the two typical stations on the Yellow River Region, including the annual maximum flood magnitude (AMFM), the ...
Xin Tong, Dong Wang, Jichun Wu, Yuanfang Chen, Xi Chen   +4 more
doaj   +1 more source

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

Annals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski, Freddy Chafota, Fangyuan Cao, Amanda Wei Yin Lim, Victor Flores‐Ocampo, Santiago Díaz‐Torres, Zuriel Ceja, Luis M. García‐Marín, Scott F. Farrell, Kishore R. Kumar, Jane Alty, George D. Mellick, Trung Thành Ngô, Miguel E. Rentería   +13 more
wiley   +1 more source

Bivariate quantitative Bayesian LASSO for detecting association of rare haplotypes with two correlated continuous phenotypes

Frontiers in Genetics, 2023
In genetic association studies, the multivariate analysis of correlated phenotypes offers statistical and biological advantages compared to analyzing one phenotype at a time. The joint analysis utilizes additional information contained in the correlation
Ibrahim Hossain Sajal, Swati Biswas
doaj   +1 more source

Perceptions about asymptomatic hyperuricemia and views about urate‐lowering therapy in people with asymptomatic hyperuricemia

Arthritis Care &Research, Accepted Article.
Background/Aims Asymptomatic hyperuricemia is a precursor of gout and is also associated with cardiovascular disease and chronic kidney disease. The aim of this study was to understand perceptions about asymptomatic hyperuricemia and views about urate‐lowering therapy in people with asymptomatic hyperuricemia.
Nicola Dalbeth, Sarah Stewart, Gregory D Gamble, Borislav Mihov, Lisa K Stamp, Janine Haslett, William J Taylor, Tony R Merriman, Adwoa Dansoa Tabi‐Amponsah, Anne Horne, Tuhina Neogi, Tristan Pascart, Mariano Andrés, Maria‐Luisa Peral‐Garrido, Eleonora Norkuviene, Janitzia Vazquez Mellado, Till Uhlig, Mingshu Sun, Changgui Li, Keith J Petrie   +19 more
wiley   +1 more source