Results 51 to 60 of about 319,699 (289)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

New Results on the Sequence Spaces Inclusion Equations of the Form $F\subset \mathcal{E}+F_x^{\prime }$ Where F, F′ ∈ {w₀, w, w_∞}

Axioms, 2023
We determine the multipliers M(X,Y) where X, Y∈{w0,w,w∞}, and we apply these results to the solvability of both the (SSIE) of the form F⊂E+wx, where F∈{w0,w,w∞}, and the (SSIE) w⊂E+Wx0 and w⊂E+Wx.
Bruno de Malafosse, Eberhard Malkowsky, Vladimir Rakočević   +2 more
doaj   +1 more source

Max-plus fundamental solution semigroups for a class of difference Riccati equations [PDF]

, 2015
Recently, a max-plus dual space fundamental solution semigroup for a class of difference Riccati equation (DRE) has been developed. This fundamental solution semigroup is represented in terms of the kernel of a specific max-plus linear operator that ...
Dower, Peter M., Zhang, Huan
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

On some binomial B ( m ) $B^{(m)}$ -difference sequence spaces

Journal of Inequalities and Applications, 2017
In this paper, we introduce the binomial sequence spaces b 0 a , b ( B ( m ) ) $b^{a,b}_{0}(B^{(m)})$ , b c a , b ( B ( m ) ) $b^{a,b}_{c}(B^{(m)})$ and b ∞ a , b ( B ( m ) ) $b^{a,b}_{\infty}(B^{(m)})$ by combining the binomial transformation and ...
Jian Meng, Meimei Song
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The binomial sequence spaces which include the spaces ℓ p $\ell_{p}$ and ℓ ∞ $\ell_{\infty}$ and geometric properties

Journal of Inequalities and Applications, 2016
In this work, we introduce the binomial sequence spaces b p r , s $b^{r,s}_{p}$ and b ∞ r , s $b^{r,s}_{\infty}$ which include the spaces ℓ p $\ell_{p}$ and ℓ ∞ $\ell _{\infty}$ , in turn. Moreover, we show that the spaces b p r , s $b^{r,s}_{p}$ and b ∞
Mustafa Cemil Bişgin
doaj   +1 more source

Continuous flows driving branching processes and their nonlinear evolution equations

Advances in Nonlinear Analysis, 2022
We consider on M(ℝd) (the set of all finite measures on ℝd) the evolution equation associated with the nonlinear operator F↦ΔF′+∑k⩾1bkFkF \mapsto \Delta F' + \sum\nolimits_{k \geqslant 1} b_k F^k , where F′ is the variational derivative of F and we show
Beznea Lucian, Vrabie Cătălin Ioan
doaj   +1 more source

Covariant Dirac Operators on Quantum Groups

, 2011
We give a construction of a Dirac operator on a quantum group based on any simple Lie algebra of classical type. The Dirac operator is an element in the vector space $U_q(\g) \otimes \mathrm{cl}_q(\g)$ where the second tensor factor is a $q$-deformation ...
Antti J. Harju, Connes A., Drinfeld V. G.   +2 more
core   +1 more source