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Molecular Genetics of the BK Virus
2007The BK Virus (BKV) genome is a double-stranded, circular DNA molecule with genetic organization similar to other polyomaviruses, and high homology to JC Virus (JCV) and SV40. The archetypal form of BKV noncoding regulatory region (NCRR) is the infectious form of BKV that replicates in the urothelium and is excreted in the urine. Rearranged forms of the
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Glomerular changes in BK virus nephropathy
Human Pathology, 2004This study seeks to define the glomerular changes that are associated with human BK virus nephropathy (BKVN). It is based on histopathologic review of 124 biopsies showing light-microscopic changes of viral nephropathy. The diagnosis of BKVN was confirmed by immunohistochemistry or by in situ hybridization. Histological lesions were scored by the Banff
Betul, Celik, Parmjeet S, Randhawa
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Cellular immune responses to BK virus
Current Opinion in Organ Transplantation, 2008Defects in cellular immunity to persistent viral infections are associated with an increased frequency and severity of viral diseases after transplantation. Polyomavirus BK (BKV) infection has emerged as an important cause of virus-related nephropathy after kidney allograft. Cell-mediated immunity seems to have a central role in preserving BKV latency.
Comoli, P., Hirsch, H. H., Ginevri, F.
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BK virus nephropathy and multiorgan involvement in a child with heart transplantation .
Clinical Nephrology, 2019BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients.
Yeonhee Lee, Yae-Jean Kim, Heeyeon Cho
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BK Virus in the Kidney Transplant Patient
The American Journal of the Medical Sciences, 2013BK virus, a member of the polyomavirus family, is a well-recognized cause of irreversible graft failure after kidney transplantation. Awareness of the relationship between BK infection and immunosuppression along with better understanding of its pathogenesis has contributed to increasing rates of its diagnosis.
Sarat, Kuppachi +2 more
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BK virus nephropathy in a native kidney
Pediatric NephrologyBK virus is a polyoma virus which has been associated with impaired graft function in kidney transplant recipients. After primary infection, the virus becomes latent in the renal/urinary epithelium. In immunocompetent hosts, there are usually no pathological sequelae.An 11-year-old female on chronic immunosuppression for a severe auto-immune ...
Dermot Wildes +6 more
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Cervical cancer prevention and control in women living with human immunodeficiency virus
Ca-A Cancer Journal for Clinicians, 2021Philip E Castle, Vikrant V Sahasrabuddhe
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Evidence for BK virus as a human tumor virus
2001ND
CORALLINI, Alfredo +3 more
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Towards an integrative view of virus phenotypes
Nature Reviews Microbiology, 2021John P Delong +2 more
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